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CATH Superfamily 3.40.718.10

Isopropylmalate Dehydrogenase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isopropylmalate Dehydrogenase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: 4-hydroxythreonine-4-phosphate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 20 P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA)
(10 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 20 P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA)
(10 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 20 P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI) P19624 (/IPI)
(10 more)
4-hydroxythreonine-4-phosphate dehydrogenase activity GO:0050570
Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+.
 20 P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA)
(10 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
 20 P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA) P19624 (/IDA)
(10 more)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
 6 Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyridoxine biosynthetic process GO:0008615
The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.
 20 P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP)
(10 more)
Pyridoxal phosphate biosynthetic process GO:0042823
The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.
 20 P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP) P19624 (/IMP)
(10 more)
Pyridoxine biosynthetic process GO:0008615
The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.
 6 Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS) Q9KUS1 (/ISS)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.