The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Methylmalonate-semialdehyde dehydrogenase [acylati...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
35 P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q54I10 (/ISS) Q723T1 (/ISS) Q723T1 (/ISS) Q723T1 (/ISS)
(25 more)
Malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478
Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
7 P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS)
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
6 P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q02253 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q02252 (/HDA) Q02252 (/HDA)
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
2 Q02253 (/IDA) Q07536 (/IDA)
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
2 Q02252 (/IMP) Q02252 (/IMP)
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
2 Q02252 (/TAS) Q02252 (/TAS)
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
1 Q07536 (/IDA)
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
1 Q9EQ20 (/ISO)
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
1 Q02253 (/NAS)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 Q0WM29 (/IDA)
Thiolester hydrolase activity GO:0016790
Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
1 Q02253 (/IDA)
Thiolester hydrolase activity GO:0016790
Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
1 Q9EQ20 (/ISO)
Malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478
Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
1 Q02253 (/IDA)
Malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478
Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
1 Q9EQ20 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
26 Q723T1 (/ISS) Q723T1 (/ISS) Q723T1 (/ISS) Q81QB6 (/ISS) Q81QR5 (/ISS) Q81QR5 (/ISS) Q81QR5 (/ISS) Q81QR5 (/ISS) Q81QR5 (/ISS) Q81QR5 (/ISS)
(16 more)
Valine metabolic process GO:0006573
The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.
8 P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS) Q83D19 (/ISS)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
8 Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA)
Thymine metabolic process GO:0019859
The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
7 P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS)
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
2 Q02252 (/IMP) Q02252 (/IMP)
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
2 Q02252 (/IMP) Q02252 (/IMP)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
2 Q02252 (/TAS) Q02252 (/TAS)
Pyrimidine nucleobase metabolic process GO:0006206
The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
1 Q7KW39 (/ISS)
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q02253 (/IDA)
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q9EQ20 (/ISO)
Valine metabolic process GO:0006573
The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.
1 Q02253 (/IDA)
Valine metabolic process GO:0006573
The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.
1 Q9EQ20 (/ISO)
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
1 Q02253 (/IDA)
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
1 Q9EQ20 (/ISO)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q0WM29 (/IDA)
Beta-alanine catabolic process GO:0019484
The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
1 Q02253 (/IDA)
Beta-alanine catabolic process GO:0019484
The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
1 Q9EQ20 (/ISO)
Thymine metabolic process GO:0019859
The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q02253 (/IDA)
Thymine metabolic process GO:0019859
The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q9EQ20 (/ISO)
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q9EQ20 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 A0A024R6G4 (/IDA) A0A024R6G4 (/IDA) Q02252 (/IDA) Q02252 (/IDA) Q0WM29 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A024R6G4 (/IDA) A0A024R6G4 (/IDA) Q02252 (/IDA) Q02252 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P52713 (/HDA) Q9EQ20 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q54I10 (/ISS) Q7KW39 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q02252 (/NAS) Q02252 (/NAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q02252 (/TAS) Q02252 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9EQ20 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9EQ20 (/ISO)