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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: 4-trimethylaminobutyraldehyde dehydrogenase isofor...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
  • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
  • Formerly EC 1.1.1.70.
 11 B0S7W4 B0S7W4 P49189 Q19A30 Q2KJH9 Q5R8A4 Q7ZVB2 Q7ZVB2 Q802W2 Q9JLJ2
(1 more...)
4-trimethylammoniobutyraldehyde dehydrogenase. [EC: 1.2.1.47]
4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH.
    		 5 P49189 Q2KJH9 Q5R8A4 Q9JLJ2 Q9JLJ3
    Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]
    4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.
    • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
    • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
    • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
    • Formerly EC 1.5.1.35.
    		 1 P49189