The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Ubiquitin carboxyl-terminal hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
24 A1L2G3 (/ISS) A2VDM8 (/ISS) A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS)
(14 more)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
24 A1L2G3 (/ISS) A2VDM8 (/ISS) A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS)
(14 more)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
24 A1L2G3 (/ISS) A2VDM8 (/ISS) A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS)
(14 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q7K5N4 (/IPI) Q92560 (/IPI) Q92560 (/IPI) Q99PU7 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 Q7K5N4 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
3 Q7K5N4 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
3 Q7K5N4 (/IMP) Q92560 (/IMP) Q92560 (/IMP)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 Q92560 (/NAS) Q92560 (/NAS)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
2 Q92560 (/IDA) Q92560 (/IDA)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
2 Q92560 (/TAS) Q92560 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q99PU7 (/ISO)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q99PU7 (/ISO)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
1 Q99PU7 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Monoubiquitinated histone H2A deubiquitination GO:0035522
The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
24 A1L2G3 (/ISS) A2VDM8 (/ISS) A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS)
(14 more)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
16 A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS) B4KT51 (/ISS) B4LQ24 (/ISS)
(6 more)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Protein K48-linked deubiquitination GO:0071108
A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
3 A2VDM8 (/ISS) D3ZHS6 (/ISS) Q99PU7 (/ISS)
Monoubiquitinated histone H2A deubiquitination GO:0035522
The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
3 Q7K5N4 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
2 Q92560 (/IMP) Q92560 (/IMP)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
2 Q92560 (/NAS) Q92560 (/NAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q92560 (/TAS) Q92560 (/TAS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 Q92560 (/IDA) Q92560 (/IDA)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 Q92560 (/TAS) Q92560 (/TAS)
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
2 Q92560 (/IDA) Q92560 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q92560 (/IDA) Q92560 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
2 Q92560 (/IMP) Q92560 (/IMP)
Protein K48-linked deubiquitination GO:0071108
A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
2 Q92560 (/IMP) Q92560 (/IMP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
2 Q92560 (/HMP) Q92560 (/HMP)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 Q99PU7 (/ISO)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 Q7K5N4 (/IMP)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 A1L2G3 (/IMP)
Specification of segmental identity, abdomen GO:0007385
The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
1 Q7K5N4 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q99PU7 (/ISO)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 Q99PU7 (/IMP)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q99PU7 (/ISO)
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
1 Q99PU7 (/ISO)
Monoubiquitinated histone H2A deubiquitination GO:0035522
The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
1 Q99PU7 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PNY8 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q99PU7 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q99PU7 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q99PU7 (/ISO)
Macrophage homeostasis GO:0061519
The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
1 Q99PU7 (/IMP)
Protein K48-linked deubiquitination GO:0071108
A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
1 Q99PU7 (/ISO)
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q99PU7 (/IMP)
Cranial skeletal system development GO:1904888
The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
1 A1L2G3 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
PR-DUB complex GO:0035517
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
24 A1L2G3 (/ISS) A2VDM8 (/ISS) A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS)
(14 more)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
16 A7SU48 (/ISS) B0W2R4 (/ISS) B3MIV9 (/ISS) B3NPV7 (/ISS) B4GAM2 (/ISS) B4GAM2 (/ISS) B4HST0 (/ISS) B4JW98 (/ISS) B4KT51 (/ISS) B4LQ24 (/ISS)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 A1L2G3 (/ISS) A2VDM8 (/ISS) C4A0D9 (/ISS) D3ZHS6 (/ISS) Q52L14 (/ISS) Q5F3N6 (/ISS) Q66JB6 (/ISS) Q99PU7 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 A0A024R305 (/IDA) A0A024R305 (/IDA) F8W6N3 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A0A024R305 (/IDA) A0A024R305 (/IDA) F8W6N3 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q7K5N4 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
PR-DUB complex GO:0035517
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
3 Q7K5N4 (/IDA) Q92560 (/IDA) Q92560 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q92560 (/TAS) Q92560 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q92560 (/TAS) Q92560 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q92560 (/IDA) Q92560 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q7K5N4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q99PU7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q99PU7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99PU7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q99PU7 (/ISO)
PR-DUB complex GO:0035517
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
1 Q7K5N4 (/IPI)
PR-DUB complex GO:0035517
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
1 Q99PU7 (/ISO)