The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: Pyruvate decarboxylase isozyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
15 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P26263 (/IDA)
(5 more)
Branched-chain-2-oxoacid decarboxylase activity GO:0047433
Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2).
9 P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P06169 (/IMP) P16467 (/IMP) P16467 (/IMP) P16467 (/IMP) P16467 (/IMP)
Carboxy-lyase activity GO:0016831
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
6 Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP)
Phenylpyruvate decarboxylase activity GO:0050177
Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2.
6 Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
4 P26263 (/IMP) P26263 (/IMP) P26263 (/IMP) P26263 (/IMP)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
2 Q07471 (/IPI) Q07471 (/IPI)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
2 Q92345 (/ISM) Q9P7P6 (/ISM)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
2 C8VE96 (/RCA) P87208 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q07471 (/IPI) Q07471 (/IPI)
Carboxy-lyase activity GO:0016831
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
2 A0A0F7RHL6 (/ISS) A0A0F7RHL6 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P33287 (/IPI) P33287 (/IPI)
Branched-chain-2-oxoacid decarboxylase activity GO:0047433
Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2).
2 Q6QBS4 (/IDA) Q6QBS4 (/IDA)
Pyruvate decarboxylase activity GO:0004737
Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
1 Q09737 (/ISO)
Phenylpyruvate decarboxylase activity GO:0050177
Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2.
1 P87208 (/RCA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aromatic amino acid family catabolic process to alcohol via Ehrlich pathway GO:0000949
The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
19 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(9 more)
L-phenylalanine catabolic process GO:0006559
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
19 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(9 more)
Tryptophan catabolic process GO:0006569
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
19 P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P06169 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P26263 (/IGI)
(9 more)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
11 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) Q6FJA3 (/IDA)
(1 more)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
9 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA)
Branched-chain amino acid catabolic process to alcohol via Ehrlich pathway GO:0000950
The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
6 Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI)
Methionine catabolic process to 3-methylthiopropanol GO:0000951
The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
6 Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
6 Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI) Q06408 (/IGI)
Leucine catabolic process GO:0006552
The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
6 Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP) Q06408 (/IMP)
L-phenylalanine catabolic process GO:0006559
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
6 Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA) Q06408 (/IDA)
Ethanol metabolic process GO:0006067
The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
4 P26263 (/IMP) P26263 (/IMP) P26263 (/IMP) P26263 (/IMP)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
4 P16467 (/IGI) P16467 (/IGI) P16467 (/IGI) P16467 (/IGI)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
3 O42873 (/NAS) Q92345 (/NAS) Q9P7P6 (/NAS)
Ethanol biosynthetic process involved in glucose fermentation to ethanol GO:0043458
The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP.
3 Q4WXX9 (/IMP) Q4WXX9 (/IMP) Q4WXX9 (/IMP)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 Q92345 (/ISM) Q9P7P6 (/ISM)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 C8VE96 (/RCA) P87208 (/RCA)
Branched-chain amino acid biosynthetic process GO:0009082
The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
2 Q6QBS4 (/IDA) Q6QBS4 (/IDA)
Indoleacetic acid biosynthetic process GO:0009684
The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.
2 A0A0F7RHL6 (/ISS) A0A0F7RHL6 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q07471 (/IMP) Q07471 (/IMP)
Positive regulation of thiamine biosynthetic process GO:0090180
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
2 Q07471 (/IMP) Q07471 (/IMP)
Positive regulation of thiamine biosynthetic process GO:0090180
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
2 Q07471 (/IPI) Q07471 (/IPI)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 Q09737 (/ISO)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 O42873 (/NAS)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
1 Q09737 (/ISO)
Penicillin biosynthetic process GO:0042318
The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
1 P87208 (/RCA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
19 P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P26263 (/HDA)
(9 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 O42873 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P06169 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA) P16467 (/HDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) P16467 (/IDA) Q07471 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 O42873 (/HDA) Q06408 (/HDA) Q06408 (/HDA) Q06408 (/HDA) Q06408 (/HDA) Q06408 (/HDA) Q06408 (/HDA) Q09737 (/HDA) Q9P7P6 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) P06169 (/IDA) Q6FJA3 (/IDA) Q6FJA3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P9WG37 (/HDA) P9WG37 (/HDA) P9WG37 (/HDA) P9WG37 (/HDA) P9WG37 (/HDA) P9WG37 (/HDA) P9WG37 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 G8BHF2 (/IDA) P83779 (/IDA) P83779 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P83779 (/IDA) P83779 (/IDA)
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
2 P83779 (/IDA) P83779 (/IDA)
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
2 P83779 (/IDA) P83779 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 P83779 (/IDA) P83779 (/IDA)