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CATH Superfamily 3.40.50.880

Class I glutamine amidotransferase (GATase) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: CTP synthase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
CTP synthase (glutamine hydrolyzing). [EC: 6.3.4.2]
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
  • The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2), and the active site where CTP synthesis takes place.
  • The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP.
  • Ammonia then reacts with this intermediate generating CTP and a phosphate.
  • The enzyme can also use ammonia from the surrounding solution.
 81 A0A024RC00 A0A024RC00 A0A0L8VW13 A0A0L8VW13 A0A0L8VW13 A0A0L8VW13 A0A0L8VW13 A0A0L8VW13 A0A1L8HE69 A0A1L8HE69
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