The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 74: Plasma membrane ferric-chelate reductase (Fre2), p...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ferric-chelate reductase activity GO:0000293
Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).
2 Q04800 (/IMP) Q4WR75 (/IMP)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 O94727 (/ISM) Q04800 (/ISM)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
2 O94727 (/ISM) Q04800 (/ISM)
Ferric-chelate reductase activity GO:0000293
Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).
1 O94727 (/ISO)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
2 Q04800 (/IMP) Q4WR75 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 O94727 (/IC)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q4WR75 (/IGI)
Copper ion import GO:0015677
The directed movement of copper ions into a cell or organelle.
1 O94727 (/ISO)
Siderophore transport GO:0015891
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O94727 (/ISS)
Reductive iron assimilation GO:0033215
A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.
1 Q04800 (/IMP)
Iron ion transmembrane transport GO:0034755
A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 O94727 (/ISO)
Copper ion transmembrane transport GO:0035434
The directed movement of copper cation across a membrane.
1 Q04800 (/ISO)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 O94727 (/HDA) Q04800 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O94727 (/ISO) Q04800 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O94727 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q04800 (/ISS)