The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

NAD(P)-binding Rossmann-like Domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 90: NADP-dependent mannitol dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mannitol 2-dehydrogenase (NADP(+)). [EC:]
D-mannitol + NADP(+) = D-fructose + NADPH.
    18 A0A1D8N824 A0A1D8N824 A0A2T4BP95 A0A2T4BP95 A0A2T4BP95 E3VWM1 E3VWM1 G0R910 G0R910 G0R910
    (8 more...)
    Sorbose reductase. [EC:]
    D-glucitol + NADP(+) = L-sorbose + NADPH.
    • The reaction occurs predominantly in the reverse direction.
    • This enzyme can also convert D-fructose into D-mannitol, but more slowly.
    2 P87219 Q9Y6Z9