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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 74: Retinol dehydrogenase type 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3(or 17)-alpha-hydroxysteroid dehydrogenase. [EC: 1.1.1.209]
Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.
  • Acts on the 3-alpha-hydroxy group of androgens of the 5-alpha- androstane series; and also, more slowly, on the 17-alpha-hydroxyl group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51).
 24 A0A024RB18 A0A024RB18 A0A2R9CIB0 A0A2R9CIB0 A0A2R9CIB0 G3RCJ0 G3RCJ0 G3RCJ0 O54909 O55240
(14 more...)
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
 24 A0A024RB18 A0A024RB18 A0A2R9CIB0 A0A2R9CIB0 A0A2R9CIB0 G3RCJ0 G3RCJ0 G3RCJ0 O54909 O55240
(14 more...)
All-trans-retinol dehydrogenase (NAD(+)). [EC: 1.1.1.105]
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all- trans-retinal-[cellular-retinol-binding-protein] + NADH.
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3-alpha-hydroxysteroids.
 24 A0A024RB43 A0A024RB43 A0A2R9CIB0 A0A2R9CIB0 A0A2R9CIB0 G3RCJ0 G3RCJ0 G3RCJ0 O14756 O14756
(14 more...)
11-cis-retinol dehydrogenase. [EC: 1.1.1.315]
11-cis-retinol-[retinal-binding-protein] + NAD(+) = 11-cis-retinal- [retinol-binding-protein] + NADH.
  • This enzyme, abundant in the retinal pigment epithelium, catalyzes the reduction of 11-cis-retinol to 11-cis-retinal while the substrate is bound to the retinal-binding protein.
  • This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin.
  • The enzyme can also accept other cis forms of retinol.
 9 A0A024RB18 A0A024RB18 O54909 O55240 O75452 P50170 Q27979 Q92781 Q92781
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). [EC: 1.1.1.239]
Testosterone + NAD(+) = androstenedione + NADH.
  • Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids.
  • Different from EC 1.1.1.50 or EC 1.1.1.213.
  • Formerly EC 1.1.1.63.
 8 A0A024RB43 A0A024RB43 O14756 O14756 O54753 P37059 P51658 Q62730
17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
 8 A0A024RB43 A0A024RB43 O14756 O14756 O54753 P37059 P51658 Q62730
3-hydroxybutyrate dehydrogenase. [EC: 1.1.1.30]
(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
  • Also oxidizes other 3-hydroxymonocarboxylic acids.
 8 A0A384MTY4 A0A384MTY4 P29147 Q02337 Q02338 Q02338 Q5ZJZ5 Q80XN0