The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 67: Malic enzyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
8 O82191 (/IDA) O82191 (/IDA) Q9CA83 (/IDA) Q9CA83 (/IDA) Q9LYG3 (/IDA) Q9LYG3 (/IDA) Q9XGZ0 (/IDA) Q9XGZ0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q9CA83 (/IDA) Q9CA83 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9CA83 (/IDA) Q9CA83 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
2 Q9CA83 (/IDA) Q9CA83 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
8 O82191 (/IDA) O82191 (/IDA) Q9CA83 (/IDA) Q9CA83 (/IDA) Q9LYG3 (/IDA) Q9LYG3 (/IDA) Q9XGZ0 (/IDA) Q9XGZ0 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
6 O82191 (/IDA) O82191 (/IDA) Q9LYG3 (/IDA) Q9LYG3 (/IDA) Q9XGZ0 (/IDA) Q9XGZ0 (/IDA)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
4 Q9CA83 (/TAS) Q9CA83 (/TAS) Q9LYG3 (/TAS) Q9LYG3 (/TAS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
2 Q9CA83 (/TAS) Q9CA83 (/TAS)
Pentose-phosphate shunt, oxidative branch GO:0009051
The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).
2 Q9LYG3 (/TAS) Q9LYG3 (/TAS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q9LYG3 (/IEP) Q9LYG3 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 Q9CA83 (/IDA) Q9CA83 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9LYG3 (/IDA) Q9LYG3 (/IDA) Q9XGZ0 (/IDA) Q9XGZ0 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 Q9CA83 (/IDA) Q9CA83 (/IDA) Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O82191 (/NAS) O82191 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
2 Q9LYG3 (/IDA) Q9LYG3 (/IDA)