View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 50: D-lactate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
 23 P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA)
(13 more)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
 23 P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA)
(13 more)
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
 8 Q8EI78 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
 23 P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP) P52643 (/IEP)
(13 more)
Mixed acid fermentation GO:0019664
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP.
 23 P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA)
(13 more)
Mixed acid fermentation GO:0019664
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP.
 23 P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP) P52643 (/IMP)
(13 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
 8 Q8EI78 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS) Q9KMX4 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 23 P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA) P52643 (/IDA)
(13 more)