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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 273: Reticulon-like protein

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-beta-hydroxysteroid-4-alpha-carboxylate 3-dehydrogenase (decarboxylating). [EC: 1.1.1.170]
A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
  • The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol.
  • It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules.
  • The first enzyme, EC 1.14.18.9, catalyzes three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyzes an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, reduces the 3-oxo group back to a 3-beta-hydroxyl.
  • If a second methyl group remains at the C-4 position, this enzyme also catalyzes its epimerization from 4-beta to 4-alpha orientation, so it could serve as a substrate for a second round of demethylation.
  • Cf. EC 1.1.1.418.
 6 A0A178W0W0 A0A178W0W0 A9X4U2 A9X4U2 Q67ZE1 Q9FX01