The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Glyoxylate/hydroxypyruvate reductase B

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    7365 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81
    (7355 more...)
    Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
    Glycolate + NADP(+) = glyoxylate + NADPH.
    • Also reduces hydroxypyruvate to glycerate.
    • Has some affinity for NAD(+).
    7365 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81 A0A026UU81
    (7355 more...)
    Gluconate 2-dehydrogenase. [EC: 1.1.1.215]
    D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH.
    • Also acts on L-idonate, D-galactonate and D-xylonate.
    134 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4 A0A037YLL4
    (124 more...)
    Glyoxylate reductase. [EC: 1.1.1.26]
    Glycolate + NAD(+) = glyoxylate + NADH.
    • Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.
    51 A0A0L8VJ46 A0A0L8VJ46 A0A0L8VJ46 A0A0L8VJ46 A0A0L8VJ46 A0A0L8VJ46 A0A0L8VJ46 B1L765 B3LPB3 B3LPB3
    (41 more...)