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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: D-3-phosphoglycerate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphoglycerate dehydrogenase activity GO:0004617
Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
 151 P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA)
(141 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 151 P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA)
(141 more)
2-hydroxyglutarate dehydrogenase activity GO:0047545
Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
 151 P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA)
(141 more)
Serine binding GO:0070905
Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid.
 151 P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA)
(141 more)
Phosphoglycerate dehydrogenase activity GO:0004617
Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
 10 P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40510 (/IMP) P40510 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 10 P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40054 (/IPI) P40510 (/IPI) P40510 (/IPI)
Alpha-ketoglutarate reductase activity GO:0061759
Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor.
 10 P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40054 (/IDA) P40510 (/IDA) P40510 (/IDA)
Alpha-ketoglutarate reductase activity GO:0061759
Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor.
 10 P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40054 (/IGI) P40510 (/IGI) P40510 (/IGI)
Alpha-ketoglutarate reductase activity GO:0061759
Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor.
 10 P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40510 (/IMP) P40510 (/IMP)
Phosphoglycerate dehydrogenase activity GO:0004617
Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
 9 P87228 (/ISS) Q54UH8 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS)
Phosphoglycerate dehydrogenase activity GO:0004617
Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
 1 C8V9B1 (/RCA)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-serine biosynthetic process GO:0006564
The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
 151 P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP) P0A9T0 (/IMP)
(141 more)
Serine family amino acid biosynthetic process GO:0009070
The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
 10 P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40054 (/IMP) P40510 (/IMP) P40510 (/IMP)
L-serine biosynthetic process GO:0006564
The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
 8 P87228 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS) Q9KP92 (/ISS)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
 1 C8V9B1 (/RCA)
Serine family amino acid biosynthetic process GO:0009070
The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
 1 Q54UH8 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 151 P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA) P0A9T0 (/IDA)
(141 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 10 P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40054 (/HDA) P40510 (/HDA) P40510 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 1 P87228 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
 1 Q54UH8 (/HDA)