The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Succinate--CoA ligase [ADP-forming] subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
169 P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI) P0AGE9 (/IPI)
(159 more)
Succinate-CoA ligase (ADP-forming) activity GO:0004775
Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.
159 A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS)
(149 more)
Succinate-CoA ligase (ADP-forming) activity GO:0004775
Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.
19 P13086 (/IDA) P53598 (/IDA) P53598 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA)
(9 more)
Nucleoside diphosphate kinase activity GO:0004550
Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
14 Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA)
(4 more)
Succinate-CoA ligase (GDP-forming) activity GO:0004776
Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
3 Q94522 (/ISS) Q94522 (/ISS) Q94522 (/ISS)
Succinyl-CoA hydrolase activity GO:0004778
Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.
3 Q94522 (/IMP) Q94522 (/IMP) Q94522 (/IMP)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
3 P68209 (/IDA) P68209 (/IDA) Q8LAD2 (/IDA)
Succinate-CoA ligase (ADP-forming) activity GO:0004775
Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.
2 P53598 (/IMP) P53598 (/IMP)
Succinate-CoA ligase (GDP-forming) activity GO:0004776
Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
2 P13086 (/IDA) P36967 (/IDA)
Succinate-CoA ligase (GDP-forming) activity GO:0004776
Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
2 Q5BAY5 (/RCA) Q5BAY5 (/RCA)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
2 P68209 (/IDA) P68209 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P53597 (/HDA)
Succinate-CoA ligase activity GO:0004774
Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA.
1 Q5A8X6 (/NAS)
Succinate-CoA ligase (ADP-forming) activity GO:0004775
Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.
1 Q9WUM5 (/ISO)
Succinate-CoA ligase (GDP-forming) activity GO:0004776
Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
1 Q9WUM5 (/ISO)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
1 P13086 (/IDA)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
1 Q9WUM5 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P13086 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9WUM5 (/ISO)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
169 P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP) P0AGE9 (/IMP)
(159 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
163 A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS) A0A1S0QL27 (/ISS)
(153 more)
Nucleoside triphosphate biosynthetic process GO:0009142
The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
14 Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA)
(4 more)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
5 P13086 (/IDA) P53598 (/IDA) P53598 (/IDA) Q6DQL1 (/IDA) Q8GTQ9 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
3 P13086 (/IDA) Q6DQL1 (/IDA) Q8GTQ9 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
3 Q94522 (/IMP) Q94522 (/IMP) Q94522 (/IMP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
3 P53597 (/TAS) P53598 (/TAS) P53598 (/TAS)
Succinate metabolic process GO:0006105
The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
3 P13086 (/IDA) Q6DQL1 (/IDA) Q8GTQ9 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2 Q5BAY5 (/RCA) Q5BAY5 (/RCA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P68209 (/IEP) P68209 (/IEP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 Q9WUM5 (/ISO)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
1 Q9WUM5 (/ISO)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
1 O13750 (/ISS)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
1 P36967 (/TAS)
Succinate metabolic process GO:0006105
The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
1 Q9WUM5 (/ISO)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
170 P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA)
(160 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
169 P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA) P0AGE9 (/HDA)
(159 more)
Succinate-CoA ligase complex (ADP-forming) GO:0009361
A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.
169 P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA) P0AGE9 (/IDA)
(159 more)
Succinate-CoA ligase complex GO:0042709
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.
14 Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA) Q51567 (/IDA)
(4 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P13086 (/IDA) P53597 (/IDA) P53598 (/IDA) P53598 (/IDA) P68209 (/IDA) P68209 (/IDA) Q582T6 (/IDA) Q6DQL1 (/IDA) Q8GTQ9 (/IDA) Q8LAD2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 O13750 (/HDA) P53596 (/HDA) P53598 (/HDA) P53598 (/HDA) Q94522 (/HDA) Q94522 (/HDA) Q94522 (/HDA) Q9WUM5 (/HDA)
Succinate-CoA ligase complex (GDP-forming) GO:0045244
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
3 Q94522 (/ISS) Q94522 (/ISS) Q94522 (/ISS)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 P68209 (/IDA) P68209 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
2 P53598 (/IDA) P53598 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q5ZL83 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9WUM5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q582T6 (/RCA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P53597 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9WUM5 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P53597 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P53597 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WUM5 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P36967 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P13086 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9WUM5 (/ISO)
Succinate-CoA ligase complex GO:0042709
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.
1 O13750 (/IC)
Succinate-CoA ligase complex (GDP-forming) GO:0045244
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
1 P13086 (/IDA)
Succinate-CoA ligase complex (GDP-forming) GO:0045244
A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
1 Q9WUM5 (/ISO)