The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 145: Retinol dehydrogenase 12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
11 Q8NBN7 (/IDA) Q8NBN7 (/IDA) Q8NBN7 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA)
(1 more)
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
10 A0A0B4KFB3 (/ISS) A1Z729 (/ISS) E1BM93 (/ISS) P59837 (/ISS) Q7JUS1 (/ISS) Q7JYX2 (/ISS) Q8BYK4 (/ISS) Q8CEE7 (/ISS) Q8MZG9 (/ISS) Q9W404 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q8TC12 (/IPI) Q8TC12 (/IPI) Q8TC12 (/IPI) Q96NR8 (/IPI) Q96NR8 (/IPI) Q96NR8 (/IPI) Q96NR8 (/IPI) Q96NR8 (/IPI)
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
8 Q8NBN7 (/TAS) Q8NBN7 (/TAS) Q8NBN7 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
6 Q8BYK4 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
6 P59837 (/ISS) Q8BYK4 (/ISS) Q8TC12 (/ISS) Q8TC12 (/ISS) Q8TC12 (/ISS) Q9QYF1 (/ISS)
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
3 Q8TC12 (/TAS) Q8TC12 (/TAS) Q8TC12 (/TAS)
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
3 Q8BYK4 (/ISO) Q8CEE7 (/ISO) Q9QYF1 (/ISO)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
1 Q8BYK4 (/ISO)
Aldehyde dehydrogenase (NADP+) activity GO:0033721
Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.
1 Q9QYF1 (/IDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
10 Q8BYK4 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q9QYF1 (/IDA)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
8 Q8TC12 (/TAS) Q8TC12 (/TAS) Q8TC12 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
7 Q8BYK4 (/IMP) Q96NR8 (/IMP) Q96NR8 (/IMP) Q96NR8 (/IMP) Q96NR8 (/IMP) Q96NR8 (/IMP) Q9QYF1 (/IMP)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
6 Q8BYK4 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA) Q96NR8 (/IDA)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
6 P59837 (/ISS) Q8BYK4 (/ISS) Q8TC12 (/ISS) Q8TC12 (/ISS) Q8TC12 (/ISS) Q9QYF1 (/ISS)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
6 Q8NBN7 (/IDA) Q8NBN7 (/IDA) Q8NBN7 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
5 Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
5 Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
3 Q8TC12 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
2 Q8CEE7 (/ISO) Q9QYF1 (/ISO)
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
2 Q8BYK4 (/ISO) Q9QYF1 (/ISO)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 Q9QYF1 (/ISO)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 E1BM93 (/ISS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 Q8BYK4 (/ISO)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 P59837 (/ISS)
Response to high light intensity GO:0009644
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
1 Q8CEE7 (/IMP)
Retina layer formation GO:0010842
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
1 Q8CEE7 (/IMP)
Adaptation of rhodopsin mediated signaling GO:0016062
The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
1 Q9QYF1 (/IMP)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
1 Q8CEE7 (/IMP)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
1 Q9QYF1 (/IMP)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
1 Q8BYK4 (/ISO)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
1 Q8CEE7 (/ISS)
Cellular detoxification of aldehyde GO:0110095
Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
1 P59837 (/ISS)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
6 P59837 (/ISS) Q96NR8 (/ISS) Q96NR8 (/ISS) Q96NR8 (/ISS) Q96NR8 (/ISS) Q96NR8 (/ISS)
Photoreceptor inner segment membrane GO:0060342
The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
5 Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS) Q96NR8 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 Q8NBN7 (/IDA) Q8NBN7 (/IDA) Q8NBN7 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 Q8NBN7 (/TAS) Q8NBN7 (/TAS) Q8NBN7 (/TAS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
3 Q8TC12 (/IDA) Q8TC12 (/IDA) Q8TC12 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
3 Q8TC12 (/TAS) Q8TC12 (/TAS) Q8TC12 (/TAS)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
2 Q8BYK4 (/IDA) Q9QYF1 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
2 A1Z729 (/HDA) Q960C7 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8CEE7 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8CEE7 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8CEE7 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9QYF1 (/ISO)