The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 131: Short-chain dehydrogenase/reductase 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
1 O88876 (/IMP)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
1 Q9W3K9 (/ISS)
Steroid dehydrogenase activity GO:0016229
Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.
1 Q9VKB8 (/ISS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 O88876 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q6GNT6 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
1 O88876 (/IMP)
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q6GNT6 (/IMP)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 O88876 (/IMP)
Regulation of retinoic acid receptor signaling pathway GO:0048385
Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 Q6DBS5 (/IMP)
Negative regulation of retinoic acid receptor signaling pathway GO:0048387
Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 O88876 (/IMP)
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
1 O88876 (/IMP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 O88876 (/IMP)
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
1 O88876 (/IMP)
Negative regulation of retinoic acid biosynthetic process GO:1900053
Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process.
1 Q6GNT6 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
4 O75911 (/TAS) O75911 (/TAS) O75911 (/TAS) O75911 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9W3K9 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 Q9W3K9 (/IDA)