The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Malate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
8 K0J107 (/ISS) K0J107 (/ISS) P00346 (/ISS) Q32LG3 (/ISS) Q4R568 (/ISS) Q5NVR2 (/ISS) Q9VEB1 (/ISS) Q9VEB1 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
7 K0J107 (/ISS) K0J107 (/ISS) P04636 (/ISS) P08249 (/ISS) Q32LG3 (/ISS) Q4R568 (/ISS) Q5NVR2 (/ISS)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
5 B4FRJ1 (/IDA) B4FRJ1 (/IDA) P04636 (/IDA) Q9VEB1 (/IDA) Q9VEB1 (/IDA)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
4 P04636 (/IDA) P08249 (/IDA) P40926 (/IDA) P40926 (/IDA)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
3 P40926 (/IMP) P40926 (/IMP) Q9ZP06 (/IMP)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P40926 (/HDA) P40926 (/HDA)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 Q9LKA3 (/IDA) Q9ZP06 (/IDA)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
2 C8V0H6 (/RCA) C8V1V3 (/RCA)
L-lactate dehydrogenase activity GO:0004459
Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
1 C8V0H6 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P04636 (/IPI)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 P08249 (/ISA)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 P08249 (/ISO)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 B3H560 (/ISS)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
1 Q9LKA3 (/IGI)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
1 P08249 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P00346 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 P04636 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 P08249 (/ISO)
Malate dehydrogenase (NADP+) activity GO:0046554
Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+.
1 P04636 (/IDA)
Malate dehydrogenase (NADP+) activity GO:0046554
Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+.
1 P08249 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 P00346 (/IPI)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Internal protein amino acid acetylation GO:0006475
The addition of an acetyl group to a non-terminal amino acid in a protein.
8 K0J107 (/ISS) K0J107 (/ISS) P00346 (/ISS) P04636 (/ISS) P08249 (/ISS) Q32LG3 (/ISS) Q4R568 (/ISS) Q5NVR2 (/ISS)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
7 K0J107 (/ISS) K0J107 (/ISS) P00346 (/ISS) P08249 (/ISS) Q32LG3 (/ISS) Q4R568 (/ISS) Q5NVR2 (/ISS)
Regulation of fatty acid beta-oxidation GO:0031998
Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.
6 B3H560 (/IMP) O82399 (/IMP) O82399 (/IMP) O82399 (/IMP) Q9ZP05 (/IMP) Q9ZP05 (/IMP)
Regulation of photorespiration GO:0080093
Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved.
6 B3H560 (/IMP) O82399 (/IMP) O82399 (/IMP) O82399 (/IMP) Q9ZP05 (/IMP) Q9ZP05 (/IMP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
3 P04636 (/IDA) Q9VEB1 (/IDA) Q9VEB1 (/IDA)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
3 P04636 (/IDA) P40926 (/IDA) P40926 (/IDA)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 P40926 (/TAS) P40926 (/TAS)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2 Q9VEB1 (/ISS) Q9VEB1 (/ISS)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2 C8V0H6 (/RCA) C8V1V3 (/RCA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2 P40926 (/TAS) P40926 (/TAS)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
2 P40926 (/IMP) P40926 (/IMP)
Internal protein amino acid acetylation GO:0006475
The addition of an acetyl group to a non-terminal amino acid in a protein.
2 P40926 (/IDA) P40926 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
2 P40926 (/IDA) P40926 (/IDA)
Salivary gland histolysis GO:0035070
The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Larval midgut cell programmed cell death GO:0035096
The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Pupal development GO:0035209
The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q9LKA3 (/IEP) Q9ZP06 (/IEP)
Regulation of programmed cell death GO:0043067
Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Positive regulation of programmed cell death GO:0043068
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 Q9VEB1 (/IMP) Q9VEB1 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 Q9VEB1 (/IDA) Q9VEB1 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 P08249 (/ISO)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 P04636 (/IDA)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 P08249 (/ISO)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
1 P08249 (/ISA)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
1 P08249 (/ISO)
Internal protein amino acid acetylation GO:0006475
The addition of an acetyl group to a non-terminal amino acid in a protein.
1 P08249 (/ISO)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 P04636 (/IDA)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 P08249 (/ISO)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
1 P08249 (/ISO)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q9ZP06 (/IEP)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
1 C8V0H6 (/RCA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q9ZP06 (/IEP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 B3H560 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q9ZP06 (/IEP)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 A0A024R4K3 (/IDA) A0A024R4K3 (/IDA) P04636 (/IDA) P40926 (/IDA) P40926 (/IDA) Q9LKA3 (/IDA) Q9VEB1 (/IDA) Q9VEB1 (/IDA) Q9ZP06 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
8 K0J107 (/ISS) K0J107 (/ISS) P08249 (/ISS) Q32LG3 (/ISS) Q4R568 (/ISS) Q5NVR2 (/ISS) Q9VEB1 (/ISS) Q9VEB1 (/ISS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
6 B3H560 (/IDA) O82399 (/IDA) O82399 (/IDA) O82399 (/IDA) Q9ZP05 (/IDA) Q9ZP05 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P08249 (/HDA) P40926 (/HDA) P40926 (/HDA) Q9VEB1 (/HDA) Q9VEB1 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
5 B3H560 (/IDA) O82399 (/IDA) O82399 (/IDA) O82399 (/IDA) Q9ZP06 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
3 B3H560 (/IDA) Q9LKA3 (/IDA) Q9ZP06 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P40926 (/HDA) P40926 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P40926 (/TAS) P40926 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 B4FRJ1 (/IDA) B4FRJ1 (/IDA)
Plant-type cell wall GO:0009505
A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
2 B4FRJ1 (/IDA) B4FRJ1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P40926 (/HDA) P40926 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 C8V1V3 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 Q9ZP06 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P08249 (/ISA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P08249 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P08249 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P04636 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P08249 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 B3H560 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 B3H560 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9LKA3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P08249 (/IMP)
Microbody GO:0042579
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
1 B3H560 (/ISS)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P08249 (/HDA)