The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 129: D-mannonate oxidoreductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mannitol dehydrogenase activity GO:0046029
Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH.
12 P0CX08 (/IMP) P0CX08 (/IMP) P0CX08 (/IMP) P0CX08 (/IMP) P0CX08 (/IMP) P0CX08 (/IMP) P0CX09 (/IMP) P0CX09 (/IMP) P0CX09 (/IMP) P0CX09 (/IMP)
(2 more)
Fructuronate reductase activity GO:0008866
Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH.
8 P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP)
Fructuronate reductase activity GO:0008866
Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH.
6 Q5LSP1 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS)
Mannitol 2-dehydrogenase activity GO:0050086
Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH.
4 Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
4 Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
4 Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA) Q4WQY4 (/IDA)
Mannitol 2-dehydrogenase activity GO:0050086
Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH.
1 Q5B9G5 (/RCA)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
D-glucuronate catabolic process GO:0042840
The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.
8 P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP) P39160 (/IMP)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
5 Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS) Q882C5 (/ISS)
Mannitol metabolic process GO:0019594
The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.
4 Q4WQY4 (/IC) Q4WQY4 (/IC) Q4WQY4 (/IC) Q4WQY4 (/IC)
Glucuronate catabolic process GO:0006064
The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid.
1 Q5LSP1 (/ISS)
Mannitol metabolic process GO:0019594
The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.
1 Q5B9G5 (/RCA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 Q2U100 (/IDA) Q2U100 (/IDA) Q2U100 (/IDA) Q2U100 (/IDA) Q2U100 (/IDA)