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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Glyceraldehyde-3-phosphate dehydrogenase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [EC: 1.2.1.12]
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
  • Also acts very slowly on D-glyceraldehyde and some other aldehydes.
  • Thiols can replace phosphate.
 44072 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20 A0A023PD20
(44062 more...)
Erythrose-4-phosphate dehydrogenase. [EC: 1.2.1.72]
D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH.
  • Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate.
  • Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
 25655 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7 A0A023Z2D7
(25645 more...)
Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating). [EC: 1.2.1.59]
D-glyceraldehyde 3-phosphate + phosphate + NAD(P)(+) = 3-phospho-D- glyceroyl phosphate + NAD(P)H.
  • NAD(+) and NADP(+) can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD(+)- and NADP(+)- dependent, respectively.
 130 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1 A0A063XFD1
(120 more...)
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating). [EC: 1.2.1.13]
D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = 3-phospho-D- glyceroyl phosphate + NADPH.
    		 22 A0A178VLF6 A0A178VLF6 A0A178WA64 A0A178WA64 A0A3L6FV10 A0A3L6FV10 A8HP84 A8HP84 P09043 P09044
    (12 more...)