View in Gene3D

CATH Superfamily 3.40.50.700

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADH:ubiquinone oxidoreductase-like, 20kDa subunit
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydrogenase (acceptor). [EC: 1.12.99.6]
H(2) + A = AH(2).
  • Uses molecular hydrogen for the reduction of a variety of substances.
 293 A0A023YVI5 A0A023Z2E5 A0A025C8A6 A0A025CUA6 A0A026UWD1 A0A026VAU9 A0A027ZMS3 A0A028AA56 A0A028E3K4 A0A028ED45
(283 more...)
Cytochrome-c3 hydrogenase. [EC: 1.12.2.1]
H(2) + 2 ferricytochrome c3 = 2 H(+) + 2 ferrocytochrome c3.
  • Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases).
  • Methylene blue and other acceptors can also be reduced.
 13 A0A0E0T1V6 A0A0E0T4X5 A0A0H3A9P9 A0A1K1RJS4 E1K248 P12943 P13061 P13062 P18187 P21853
(3 more...)
Coenzyme F420 hydrogenase. [EC: 1.12.98.1]
H(2) + oxidized coenzyme F420 = reduced coenzyme F420.
  • The enzyme from some sources contains selenocysteine.
  • The enzyme also reduces the riboflavin analog of F420, flavins and methylviologen, but to a lesser extent.
  • The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
  • Formerly EC 1.12.99.1.
 4 P19498 P80491 Q00393 Q60340
Hydrogen dehydrogenase (NAD(P)(+)). [EC: 1.12.1.5]
H(2) + NAD(P)(+) = H(+) + NAD(P)H.
  • The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4).
  • Different from EC 1.12.1.3.
 2 E7FHF8 I6UQE7
Hydrogen dehydrogenase (NADP(+)). [EC: 1.12.1.3]
H(2) + NADP(+) = H(+) + NADPH.
  • The protein from the bacterium Desulfovibrio fructosovorans exclusively functions as a hydrogen dehydrogenase, while the enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4).
  • Different from EC 1.12.1.5.
 2 E7FHU4 I6TWC7
Hydrogen dehydrogenase. [EC: 1.12.1.2]
H(2) + NAD(+) = H(+) + NADH.
    		 1 P22319
    Hydrogen:quinone oxidoreductase. [EC: 1.12.5.1]
    H(2) + menaquinone = menaquinol.
    • Also catalyzes the reduction of water-soluble quinones (e.g. 2,3- dimethylnaphthoquinone) or viologen dyes (benzylviologen or methylviologen) by H(2).
    • Formerly EC 1.12.99.3.
    		 1 P31884