The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: tryptophan--tRNA ligase, cytoplasmic

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
10 P32921 (/IDA) Q0KI98 (/IDA) Q12109 (/IDA) Q12109 (/IDA) Q12109 (/IDA) Q12109 (/IDA) Q12109 (/IDA) Q580R7 (/IDA) Q9U4Y0 (/IDA) Q9U4Y1 (/IDA)
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
6 P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P32921 (/IMP)
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
5 P17248 (/ISS) P32921 (/ISS) Q09692 (/ISS) Q55DZ8 (/ISS) Q6P7B0 (/ISS)
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
5 P23381 (/NAS) P23381 (/NAS) P23381 (/NAS) P23381 (/NAS) P23381 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI)
Kinase inhibitor activity GO:0019210
Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
5 P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
5 P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI) P23381 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
3 Q0KI98 (/TAS) Q9U4Y0 (/TAS) Q9U4Y1 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P17248 (/ISS) P32921 (/ISS) Q6P7B0 (/ISS)
Tryptophan-tRNA ligase activity GO:0004830
Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
1 P32921 (/ISO)
Kinase inhibitor activity GO:0019210
Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P32921 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P32921 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P32921 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P32921 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tryptophanyl-tRNA aminoacylation GO:0006436
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
13 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) Q0KI98 (/TAS) Q12109 (/TAS) Q12109 (/TAS) Q12109 (/TAS) Q12109 (/TAS)
(3 more)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
5 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS)
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
5 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS)
Tryptophanyl-tRNA aminoacylation GO:0006436
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
5 P23381 (/NAS) P23381 (/NAS) P23381 (/NAS) P23381 (/NAS) P23381 (/NAS)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
5 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Regulation of protein ADP-ribosylation GO:0010835
Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
5 P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Tryptophanyl-tRNA aminoacylation GO:0006436
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
4 P32921 (/IDA) Q0KI98 (/IDA) Q9U4Y0 (/IDA) Q9U4Y1 (/IDA)
Tryptophanyl-tRNA aminoacylation GO:0006436
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
3 Q09692 (/ISS) Q9SR15 (/ISS) Q9SR15 (/ISS)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
3 Q0KI98 (/IMP) Q9U4Y0 (/IMP) Q9U4Y1 (/IMP)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P32921 (/ISO)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
1 Q09692 (/NAS)
Tryptophanyl-tRNA aminoacylation GO:0006436
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
1 Q580R7 (/ISM)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P32921 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P32921 (/ISO)
Regulation of protein ADP-ribosylation GO:0010835
Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
1 P32921 (/ISO)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
1 P32921 (/ISO)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
1 P32921 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 A0A024R6K8 (/IDA) A0A024R6K8 (/IDA) A0A024R6K8 (/IDA) A0A024R6K8 (/IDA) A0A024R6K8 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) Q0KI98 (/TAS) Q9U4Y0 (/TAS) Q9U4Y1 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P23381 (/HDA) P23381 (/HDA) P23381 (/HDA) P23381 (/HDA) P23381 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA) P23381 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q12109 (/HDA) Q12109 (/HDA) Q12109 (/HDA) Q12109 (/HDA) Q12109 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS) P23381 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP) P23381 (/IMP)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P23381 (/HDA) P23381 (/HDA) P23381 (/HDA) P23381 (/HDA) P23381 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9SR15 (/ISS) Q9SR15 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P32921 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q580R7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9ADK8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q09692 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P32921 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P32921 (/ISO)