The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 264: Diphthine--ammonia ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Diphthine-ammonia ligase activity GO:0017178
Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate.
8 Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA)
Diphthine-ammonia ligase activity GO:0017178
Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate.
8 Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0017183
The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
8 Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA) Q12429 (/IDA)
Peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0017183
The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
8 Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP) Q12429 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PGY1 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA) Q12429 (/HDA)