The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 748: ras-related protein Rab-34 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q64008 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI)
Ral GTPase binding GO:0017160
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.
6 Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
6 Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI) Q9BZG1 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q64008 (/IDA)
Ral GTPase binding GO:0017160
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.
1 Q64008 (/ISO)
Guanyl nucleotide binding GO:0019001
Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.
1 Q64008 (/IDA)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
1 Q64008 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
8 Q06AU4 (/ISS) Q5U1Y1 (/ISS) Q9BZG1 (/ISS) Q9BZG1 (/ISS) Q9BZG1 (/ISS) Q9BZG1 (/ISS) Q9BZG1 (/ISS) Q9BZG1 (/ISS)
Phagosome-lysosome fusion GO:0090385
The creation of a phagolysosome from a phagosome and a lysosome.
7 Q64008 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP)
Antigen processing and presentation GO:0019882
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
6 Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP)
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
6 Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP) Q9BZG1 (/IMP)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
3 Q06AU4 (/ISS) Q5U1Y1 (/ISS) Q64008 (/ISS)
Phagosome-lysosome fusion GO:0090385
The creation of a phagolysosome from a phagosome and a lysosome.
3 Q06AU4 (/ISS) Q5U1Y1 (/ISS) Q64008 (/ISS)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q64008 (/IDA)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
1 Q64008 (/IDA)
Antigen processing and presentation GO:0019882
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
1 Q64008 (/ISO)
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
1 Q64008 (/ISO)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
1 Q64008 (/IGI)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
1 Q64008 (/ISO)
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
1 Q64008 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q5U1Y1 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q64008 (/ISO)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q5U1Y1 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q64008 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q64008 (/ISO)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
1 Q64008 (/ISO)
Phagosome-lysosome fusion GO:0090385
The creation of a phagolysosome from a phagosome and a lysosome.
1 Q64008 (/ISO)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q64008 (/IDA)
Positive regulation of protein localization to phagocytic vesicle GO:1905171
Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle.
1 Q64008 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
7 Q64008 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Golgi cisterna GO:0031985
Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA) Q9BZG1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
6 Q9BZG1 (/HDA) Q9BZG1 (/HDA) Q9BZG1 (/HDA) Q9BZG1 (/HDA) Q9BZG1 (/HDA) Q9BZG1 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
3 Q06AU4 (/ISS) Q5U1Y1 (/ISS) Q64008 (/ISS)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q64008 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q64008 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q64008 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q64008 (/ISO)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
1 Q64008 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q64008 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q64008 (/ISO)
Golgi cisterna GO:0031985
Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
1 Q64008 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q64008 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q64008 (/ISO)