The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 642: RuvB-like helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 G0RYI5 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
8 Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Box C/D snoRNP assembly GO:0000492
The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
8 Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
8 Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
8 Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP) Q03940 (/IMP)
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
8 Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
8 Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA)
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
8 Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA)
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
8 Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)
ASTRA complex GO:0070209
A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.
8 Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA) Q03940 (/HDA)
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
8 Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA) Q03940 (/IDA)
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
8 Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI) Q03940 (/IPI)