The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54: ABC multidrug transporter atrF

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 30 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 P32568 (/IPI) P32568 (/IPI) P33302 (/IPI) P33302 (/IPI) P51533 (/IPI) P51533 (/IPI) P51533 (/IPI) P51533 (/IPI) P53756 (/IPI) P53756 (/IPI)
(4 more)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
9 Q54TV1 (/IGC) Q54TV2 (/IGC) Q556W2 (/IGC) Q55DQ2 (/IGC) Q55DR1 (/IGC) Q8T673 (/IGC) Q8T675 (/IGC) Q8T683 (/IGC) Q9NGP5 (/IGC)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
7 P51533 (/ISS) P51533 (/ISS) P51533 (/ISS) P51533 (/ISS) Q04182 (/ISS) Q04182 (/ISS) Q9NGP5 (/ISS)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
4 O74208 (/IDA) P33302 (/IDA) P33302 (/IDA) Q6FK23 (/IDA)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
3 O74208 (/IGI) Q6FQN3 (/IGI) Q6FQN3 (/IGI)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
3 O74208 (/ISA) Q6FQN3 (/ISA) Q6FQN3 (/ISA)
Organic acid transmembrane transporter activity GO:0005342
Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage,
2 Q02785 (/IDA) Q02785 (/IDA)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2 P33302 (/IMP) P33302 (/IMP)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2 P32568 (/ISS) P32568 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P33302 (/IPI) P33302 (/IPI)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 Q5ANA3 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 Q5ANA3 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q5ANA3 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q5ANA3 (/IMP)
Phospholipid transporter activity GO:0005548
Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
1 Q5ANA3 (/IDA)
Phospholipid transporter activity GO:0005548
Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
1 Q5ANA3 (/IMP)
Fluconazole transmembrane transporter activity GO:0015244
Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ANA3 (/IDA)
Fluconazole transmembrane transporter activity GO:0015244
Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ANA3 (/IMP)
Aminophospholipid flippase activity GO:0015247
Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.
1 Q5ANA3 (/IDA)
Aminophospholipid flippase activity GO:0015247
Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.
1 Q5ANA3 (/IMP)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q5ANA3 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q5ANA3 (/IMP)
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
1 Q5ANA3 (/IDA)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
1 P41820 (/TAS)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q5ANA3 (/IGI)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q5ANA3 (/IMP)
Azole transmembrane transporter activity GO:1901474
Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.
1 Q5ANA3 (/IDA)
Azole transmembrane transporter activity GO:1901474
Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.
1 Q5ANA3 (/IGI)
Corticosterone binding GO:1903875
Interacting selectively and non-covalently with corticosterone.
1 Q5ANA3 (/IDA)
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
1 Q5ANA3 (/IDA)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
8 E9RBG1 (/IMP) E9RBG1 (/IMP) E9RBG1 (/IMP) P78595 (/IMP) Q5ANA3 (/IMP) Q6FK23 (/IMP) Q6FQN3 (/IMP) Q6FQN3 (/IMP)
Sorocarp morphogenesis GO:0031288
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.
7 Q54CG0 (/IMP) Q54TV1 (/IMP) Q556W2 (/IMP) Q55GB1 (/IMP) Q8ST66 (/IMP) Q8T675 (/IMP) Q9NGP5 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
7 P78595 (/IEP) Q4WDD4 (/IEP) Q5ANA3 (/IEP) Q5AS02 (/IEP) Q5AS02 (/IEP) Q5AT91 (/IEP) Q5AT91 (/IEP)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
7 A0A1D8PE84 (/IMP) P33302 (/IMP) P33302 (/IMP) P78595 (/IMP) Q5ANA3 (/IMP) Q5AT91 (/IMP) Q5AT91 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
6 P33302 (/IMP) P33302 (/IMP) P53756 (/IMP) P53756 (/IMP) Q04182 (/IMP) Q04182 (/IMP)
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
4 P51533 (/ISS) P51533 (/ISS) P51533 (/ISS) P51533 (/ISS)
Cellular cation homeostasis GO:0030003
Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
4 P32568 (/IGI) P32568 (/IGI) P33302 (/IGI) P33302 (/IGI)
Cellular cation homeostasis GO:0030003
Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
4 P32568 (/IMP) P32568 (/IMP) P33302 (/IMP) P33302 (/IMP)
Replication-born double-strand break repair via sister chromatid exchange GO:1990414
The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
4 P51533 (/IMP) P51533 (/IMP) P51533 (/IMP) P51533 (/IMP)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
3 Q54CG0 (/IMP) Q8T675 (/IMP) Q9NGP5 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 O74208 (/ISA) Q6FQN3 (/ISA) Q6FQN3 (/ISA)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
3 Q5ANA3 (/IDA) Q5AT91 (/IDA) Q5AT91 (/IDA)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q8ST66 (/IGI) Q9NGP5 (/IGI)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 A0A1D8PQ95 (/IMP) A0A1D8PQ95 (/IMP)
Organic acid transport GO:0015849
The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q02785 (/IDA) Q02785 (/IDA)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2 Q8ST66 (/IGI) Q9NGP5 (/IGI)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 A0A1D8PQ95 (/IMP) A0A1D8PQ95 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 A0A1D8PQ95 (/IMP) A0A1D8PQ95 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 A0A1D8PQ95 (/IMP) A0A1D8PQ95 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P32568 (/TAS) P32568 (/TAS)
Endosomal lumen acidification GO:0048388
Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion.
2 Q8ST66 (/IGI) Q9NGP5 (/IGI)
Sterol homeostasis GO:0055092
Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.
2 P53756 (/IMP) P53756 (/IMP)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 Q8T673 (/IEP)
Fluconazole transport GO:0015903
The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ANA3 (/IDA)
Fluconazole transport GO:0015903
The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ANA3 (/IMP)
Culmination involved in sorocarp development GO:0031154
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
1 Q54TV2 (/IMP)
Azole transport GO:0045117
The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q5ANA3 (/IDA)
Azole transport GO:0045117
The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q5ANA3 (/IGI)
Azole transport GO:0045117
The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6FK23 (/IMP)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
1 Q5ANA3 (/IDA)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
1 Q5ANA3 (/IMP)
Export across plasma membrane GO:0140115
The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
1 P41820 (/TAS)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
1 Q5ANA3 (/IGI)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
1 Q6FK23 (/ISA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
20 A0A1D8PE84 (/IDA) A0A1D8PQ95 (/IDA) A0A1D8PQ95 (/IDA) E9RBG1 (/IDA) E9RBG1 (/IDA) E9RBG1 (/IDA) P32568 (/IDA) P32568 (/IDA) P33302 (/IDA) P33302 (/IDA)
(10 more)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
12 P32568 (/HDA) P32568 (/HDA) P33302 (/HDA) P33302 (/HDA) P51533 (/HDA) P51533 (/HDA) P51533 (/HDA) P51533 (/HDA) Q02785 (/HDA) Q02785 (/HDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P32568 (/HDA) P32568 (/HDA) P33302 (/HDA) P33302 (/HDA) P53756 (/HDA) P53756 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
4 P51533 (/HDA) P51533 (/HDA) P51533 (/HDA) P51533 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P53756 (/ISA) P53756 (/ISA) Q6FQN3 (/ISA) Q6FQN3 (/ISA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O74208 (/IGI) Q6FQN3 (/IGI) Q6FQN3 (/IGI)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P53756 (/HDA) P53756 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P78595 (/NAS) Q5ANA3 (/NAS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q9NGP5 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q5ANA3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9NGP5 (/IGC)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9NGP5 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5ANA3 (/IDA)