The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 493: Guanine nucleotide-binding protein-like 3-like pro...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q9NVN8 (/HDA) Q9NVN8 (/HDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9NVN8 (/IPI) Q9NVN8 (/IPI)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 Q21086 (/ISS) Q6DRP2 (/ISS)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
4 A0A2R8S0C0 (/IMP) Q58EC7 (/IMP) Q6DBQ5 (/IMP) Q7SZX9 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2 Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
2 Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 Q21086 (/ISS) Q6DRP2 (/ISS)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
2 Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
2 Q9NVN8 (/IMP) Q9NVN8 (/IMP)
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467
Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
1 Q6DRP2 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q21086 (/IMP)
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
1 Q6DRP2 (/IMP)
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
1 Q6DRP2 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q21086 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q6PGG6 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q6PGG6 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q6PGG6 (/ISO)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q6PGG6 (/ISO)
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
1 Q6PGG6 (/ISO)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q21086 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 Q6DRP2 (/IMP)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q6PGG6 (/ISO)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
1 Q6PGG6 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
5 A0A024R9Y6 (/IDA) A0A024R9Y6 (/IDA) Q21086 (/IDA) Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A0A024R9Y6 (/IDA) A0A024R9Y6 (/IDA) Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A024R9Y6 (/IDA) A0A024R9Y6 (/IDA) Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q21086 (/ISS) Q6DRP2 (/ISS)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
2 Q9NVN8 (/IDA) Q9NVN8 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q21086 (/ISS) Q6DRP2 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9NVN8 (/HDA) Q9NVN8 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6PGG6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q21086 (/IDA)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
1 Q6PGG6 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q6PGG6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PGG6 (/ISO)