The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 460: RNA helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q9NVP1 (/IPI)
(1 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
9 Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
RNA-dependent ATPase activity GO:0008186
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
9 Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
9 Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI) Q03532 (/IPI)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
4 Q5AK59 (/ISS) Q5AK59 (/ISS) Q9VD51 (/ISS) Q9VD51 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q9NVP1 (/HDA) Q9NVP1 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q09916 (/ISO) Q09916 (/ISO)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 Q5AK59 (/IGI) Q5AK59 (/IGI)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 Q09916 (/ISO) Q09916 (/ISO)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 Q9NVP1 (/TAS) Q9NVP1 (/TAS)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463
Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
SnoRNA release from pre-rRNA GO:1990417
The release of snoRNA from pre-rRNA.
9 Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP) Q03532 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
3 F1QLW8 (/IMP) Q4V9K8 (/IMP) Q6DRL1 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
3 F1QLW8 (/IMP) Q4V9K8 (/IMP) Q6DRL1 (/IMP)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
2 Q09916 (/ISO) Q09916 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 Q9VD51 (/IMP) Q9VD51 (/IMP)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
2 Q5AK59 (/IGI) Q5AK59 (/IGI)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
2 Q5AK59 (/ISS) Q5AK59 (/ISS)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q5XHY0 (/IEP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
15 A0A024RAH8 (/IDA) A0A024RAH8 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
(5 more)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
9 Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
90S preribosome GO:0030686
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
9 Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA)
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
9 Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA) Q03532 (/HDA)
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
9 Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA) Q03532 (/IDA)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
3 Q54S03 (/ISS) Q8K363 (/ISS) Q8K363 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q09916 (/HDA) Q09916 (/HDA)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
2 Q9NVP1 (/IDA) Q9NVP1 (/IDA)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
2 Q8K363 (/ISO) Q8K363 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q09916 (/HDA) Q09916 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q8K363 (/ISO) Q8K363 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q8K363 (/ISS) Q8K363 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9NVP1 (/HDA) Q9NVP1 (/HDA)