Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.

The regulated release of cytokines from a cell that contributes to an immune response.

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.

Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.

Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

The removal of one or more ubiquitin groups from a protein.

Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.

Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.

The movement of a dendritic cell within or between different tissues and organs of the body.

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.

Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.

The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18.

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation.

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.

Cytoplasm situated near, or occurring around, the nucleus.

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

A cytosolic protein complex that is capable of activating caspase-1.

A cytosolic protein complex that is capable of activating caspase-1.

A cytosolic protein complex that is capable of activating caspase-1.

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.

A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.