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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 433: Estrogen sulfotransferase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aryl sulfotransferase. [EC: 2.8.2.1]
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
  • A number of aromatic compounds can act as acceptors.
  • Organic hydroxylamines are not substrates (cf. EC 2.8.2.9).
 13 P0DMM9 P0DMM9 P0DMM9 P0DMN0 P0DMN0 P0DMN0 P17988 P50225 P50226 P52840
(3 more...)
Estrone sulfotransferase. [EC: 2.8.2.4]
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
    		 11 P19217 P49887 P49888 P49888 P49889 P49890 P49891 P52844 P52845 Q53X91
    (1 more...)
    Alcohol sulfotransferase. [EC: 2.8.2.2]
    3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
    • Primary and secondary alcohols, including aliphatic alcohols, ascorbate, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15).
    		 7 O00204 O35400 P07631 P22789 P50235 Q29YR5 Q6IMI6
    Bile-salt sulfotransferase. [EC: 2.8.2.14]
    (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. (2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
    • The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species.
    • This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase.
    • In addition to the 5-beta-bile acid glycolithocholate, deoxycholate, 3-beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3-beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34).
    • May be identical to EC 2.8.2.2.
    		 7 A8K015 A8K015 P15709 P50236 P52843 Q06520 Q06520
    Amine sulfotransferase. [EC: 2.8.2.3]
    3'-phosphoadenylyl sulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate.
    • A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.
    		 1 O35403