The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 422: Guanylate-binding protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 A4UUI3 (/IPI) B2XWS1 (/IPI) P32455 (/IPI) P32456 (/IPI) P32456 (/IPI) Q5DTF3 (/IPI) Q61594 (/IPI) Q8CFB4 (/IPI) Q96PP8 (/IPI) Q96PP9 (/IPI)
(1 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 P32455 (/IDA) P32456 (/IDA) P32456 (/IDA) Q96PP8 (/IDA) Q96PP9 (/IDA) Q9H0R5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 Q01514 (/ISO) Q61107 (/ISO) Q8CFB4 (/ISO) Q9Z0E6 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
3 P32455 (/TAS) P32456 (/TAS) P32456 (/TAS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 Q61107 (/ISS) Q9Z0E6 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P32455 (/IPI) Q96PP8 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P32455 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 P32455 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P32455 (/IDA)
GMP binding GO:0019002
Interacting selectively and non-covalently with GMP, guanosine monophosphate.
1 Q01514 (/IDA)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
1 P32455 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P32455 (/IPI)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
1 P32455 (/IPI)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 P32455 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8CFB4 (/ISO)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
1 P32455 (/IPI)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
24 A0A0G2JDV3 (/IDA) A4UUI3 (/IDA) I6L9A3 (/IDA) L7N1X8 (/IDA) P32455 (/IDA) P32456 (/IDA) P32456 (/IDA) Q000W5 (/IDA) Q01514 (/IDA) Q29RG2 (/IDA)
(14 more)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
15 A0A0G2JDV3 (/IDA) Q000W5 (/IDA) Q01514 (/IDA) Q29RG2 (/IDA) Q2M1J9 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6KAN1 (/IDA) Q6PEN2 (/IDA) Q6PG83 (/IDA)
(5 more)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
15 A0A0G2JDV3 (/IDA) Q000W5 (/IDA) Q01514 (/IDA) Q29RG2 (/IDA) Q2M1J9 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6KAN1 (/IDA) Q6PEN2 (/IDA) Q6PG83 (/IDA)
(5 more)
Adhesion of symbiont to host GO:0044406
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
12 A0A0G2JDV3 (/IDA) Q01514 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6KAN1 (/IDA) Q6PEN2 (/IDA) Q6PG83 (/IDA) Q6ZQL8 (/IDA) Q78UK8 (/IDA) Q8BTS3 (/IDA)
(2 more)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
8 A0A0G2JDV3 (/IMP) Q000W5 (/IMP) Q01514 (/IMP) Q29RG2 (/IMP) Q2M1J9 (/IMP) Q3U8G5 (/IMP) Q6PEN2 (/IMP) Q6ZQL8 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
8 A0A0G2JDV3 (/IDA) Q000W5 (/IDA) Q29RG2 (/IDA) Q2M1J9 (/IDA) Q3U8G5 (/IDA) Q6PEN2 (/IDA) Q6ZQL8 (/IDA) Q9Z0E6 (/IDA)
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
7 A0A0G2JDV3 (/IDA) Q01514 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6PEN2 (/IDA) Q6ZQL8 (/IDA) Q9Z0E6 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
6 A0A0G2JDV3 (/IEP) Q3U8G5 (/IEP) Q6PEN2 (/IEP) Q6ZQL8 (/IEP) Q8CFB4 (/IEP) Q9Z0E6 (/IEP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
4 P32455 (/IEP) P32456 (/IEP) P32456 (/IEP) Q9H0R5 (/IEP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
4 P32455 (/IEP) P32456 (/IEP) P32456 (/IEP) Q9H0R5 (/IEP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 A4UUI3 (/IGI) Q5DTF3 (/IGI) Q61594 (/IGI)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
3 A4UUI3 (/IDA) Q5DTF3 (/IDA) Q61594 (/IDA)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
3 A4UUI3 (/IGI) Q5DTF3 (/IGI) Q61594 (/IGI)
Negative regulation of interferon-alpha production GO:0032687
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.
3 A4UUI3 (/IMP) Q5DTF3 (/IMP) Q61594 (/IMP)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
3 A4UUI3 (/IDA) Q5DTF3 (/IDA) Q61594 (/IDA)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
3 Q6KAN1 (/IMP) Q78UK8 (/IMP) Q91Z40 (/IMP)
Regulation of defense response to virus GO:0050688
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
3 A4UUI3 (/IMP) Q5DTF3 (/IMP) Q61594 (/IMP)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
3 P32455 (/TAS) P32456 (/TAS) P32456 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q5R9T9 (/ISS) Q6ZN66 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 P32456 (/TAS) P32456 (/TAS)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
2 P32456 (/IDA) P32456 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q5R9T9 (/ISS) Q6ZN66 (/ISS)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
2 Q8CFB4 (/IMP) Q96PP8 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P32456 (/TAS) P32456 (/TAS)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 Q96PP8 (/IEP) Q96PP9 (/IEP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 Q5R9T9 (/ISS) Q6ZN66 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 L7N1X8 (/IMP)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
1 Q96PP8 (/IDA)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
1 Q8CFB4 (/ISO)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
1 Q9Z0E6 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 L7N1X8 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q8CFB4 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q96PP8 (/ISS)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q8CFB4 (/ISO)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
1 P32455 (/IMP)
Negative regulation of T cell receptor signaling pathway GO:0050860
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
1 P32455 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P32455 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q96PP8 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q8CFB4 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q8CFB4 (/ISS)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P32455 (/IMP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 Q9Z0E6 (/ISO)
Interleukin-18 secretion GO:0072616
The regulated release of interleukin-18 from a cell.
1 Q8CFB4 (/IMP)
Interleukin-18 secretion GO:0072616
The regulated release of interleukin-18 from a cell.
1 Q96PP8 (/ISS)
Protein localization to vacuole GO:0072665
A process in which a protein is transported to, or maintained at, a location in a vacuole.
1 P32455 (/IDA)
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q8CFB4 (/IMP)
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q96PP8 (/ISS)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 P32455 (/IMP)
Negative regulation of interleukin-2 secretion GO:1900041
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion.
1 P32455 (/IMP)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 Q96PP8 (/IDA)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 Q8CFB4 (/ISO)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 Q8CFB4 (/ISS)
Regulation of protein localization to plasma membrane GO:1903076
Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.
1 P32455 (/IGI)
Negative regulation of protein localization to plasma membrane GO:1903077
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
1 P32455 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
16 A0A0G2JDV3 (/IDA) Q000W5 (/IDA) Q01514 (/IDA) Q29RG2 (/IDA) Q2M1J9 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6KAN1 (/IDA) Q6PEN2 (/IDA) Q6PG83 (/IDA)
(6 more)
Symbiont-containing vacuole membrane GO:0020005
The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.
12 A0A0G2JDV3 (/IDA) Q01514 (/IDA) Q3U8G5 (/IDA) Q61107 (/IDA) Q6KAN1 (/IDA) Q6PEN2 (/IDA) Q6PG83 (/IDA) Q6ZQL8 (/IDA) Q78UK8 (/IDA) Q8BTS3 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P32455 (/IDA) P32456 (/IDA) P32456 (/IDA) Q61107 (/IDA) Q96PP9 (/IDA) Q9H0R5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P32455 (/IDA) P32456 (/IDA) P32456 (/IDA) Q96PP8 (/IDA) Q9H0R5 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 P32455 (/IDA) P32456 (/IDA) P32456 (/IDA) Q96PP8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P32456 (/IDA) P32456 (/IDA) Q96PP8 (/IDA) Q96PP9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P32456 (/IDA) P32456 (/IDA) Q96PP9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q01514 (/ISO) Q8CFB4 (/ISO) Q9Z0E6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q01514 (/ISO) Q61107 (/ISO) Q9Z0E6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P32455 (/TAS) P32456 (/TAS) P32456 (/TAS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
3 P32455 (/IDA) P32456 (/IDA) P32456 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 Q61107 (/ISO) Q8CFB4 (/ISO) Q9Z0E6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q61107 (/ISO) Q9Z0E6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P32456 (/IDA) P32456 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q8CFB4 (/ISO) Q9Z0E6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z0E6 (/ISO)
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
1 P32455 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q9Z0E6 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q96PP8 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q6ZN66 (/HDA)