The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 394: ATP-binding cassette, sub-family C (CFTR/MRP), mem...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
6 O60706 (/IPI) O60706 (/IPI) O60706 (/IPI) O60706 (/IPI) O60706 (/IPI) Q09428 (/IPI)
Sulfonylurea receptor activity GO:0008281
Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
5 O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
5 O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
3 B2RUS7 (/ISO) P70170 (/ISO) Q8BNE2 (/ISO)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 Q09427 (/ISS) Q09429 (/ISS)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q09428 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q63563 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q63563 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P70170 (/ISO)
Sulfonylurea receptor activity GO:0008281
Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q63563 (/IDA)
Sulfonylurea receptor activity GO:0008281
Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P70170 (/ISO)
Sulfonylurea receptor activity GO:0008281
Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q63563 (/TAS)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
1 Q63563 (/IDA)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
1 P70170 (/ISO)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 Q63563 (/IPI)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 P70170 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P70170 (/ISO)

There are 56 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 O60706 (/IMP) O60706 (/IMP) O60706 (/IMP) O60706 (/IMP) O60706 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
5 O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
5 O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
5 O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of low-density lipoprotein particle clearance GO:0010989
Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q09429 (/IEP) Q63563 (/IEP)
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of glial cell proliferation GO:0060253
Any process that stops or decreases the rate or extent of glial cell proliferation.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of wound healing GO:0061045
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of neuroblast migration GO:0061855
Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Positive regulation of uterine smooth muscle relaxation GO:1900721
Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Positive regulation of voltage-gated potassium channel activity GO:1903818
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Positive regulation of tight junction disassembly GO:1905075
Any process that activates or increases the frequency, rate or extent of tight junction disassembly.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Negative regulation of maintenance of permeability of blood-brain barrier GO:1905604
Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of permeability of blood-brain barrier.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
1 Q09429 (/IMP)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63563 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P70170 (/ISO)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q09428 (/TAS)
Substrate-dependent cell migration, cell contraction GO:0006932
The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves.
1 Q63563 (/NAS)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q09429 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 Q09429 (/IMP)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 Q09429 (/IMP)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q09429 (/IDA)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q09429 (/IDA)
Negative regulation of low-density lipoprotein particle clearance GO:0010989
Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 Q09429 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 Q09429 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q09429 (/IEP)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q09429 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q09429 (/IEP)
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q09429 (/IDA)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
1 Q09429 (/IDA)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 Q09429 (/IMP)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 Q09428 (/TAS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P70170 (/ISO)
Negative regulation of glial cell proliferation GO:0060253
Any process that stops or decreases the rate or extent of glial cell proliferation.
1 Q09429 (/IMP)
Negative regulation of wound healing GO:0061045
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q09429 (/IMP)
Negative regulation of neuroblast migration GO:0061855
Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.
1 Q09429 (/IMP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q09429 (/IDA)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
1 Q63563 (/IDA)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
1 P70170 (/ISO)
Positive regulation of uterine smooth muscle relaxation GO:1900721
Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation.
1 Q09429 (/IMP)
Positive regulation of voltage-gated potassium channel activity GO:1903818
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity.
1 Q09429 (/IMP)
Positive regulation of tight junction disassembly GO:1905075
Any process that activates or increases the frequency, rate or extent of tight junction disassembly.
1 Q09429 (/IMP)
Negative regulation of maintenance of permeability of blood-brain barrier GO:1905604
Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of permeability of blood-brain barrier.
1 Q09429 (/IMP)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 Q63563 (/IDA)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 P70170 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
8 O60706 (/IDA) O60706 (/IDA) O60706 (/IDA) O60706 (/IDA) O60706 (/IDA) Q09428 (/IDA) Q09429 (/IDA) Q63563 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) O60706 (/TAS) Q09428 (/TAS)
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
5 O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS) O60706 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 B2RUS7 (/IDA) P70170 (/IDA) Q63563 (/IDA) Q8BNE2 (/IDA)
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
3 B2RUS7 (/ISO) P70170 (/ISO) Q8BNE2 (/ISO)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 B2RUS7 (/ISO) Q8BNE2 (/ISO)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 Q63563 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 P70170 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q63563 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P70170 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70170 (/ISO)
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
1 Q63563 (/TAS)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 P70170 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 Q63563 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P70170 (/ISO)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
1 Q09429 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q09429 (/IDA)