The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 359: Small GTP-binding protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
12 P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI)
(2 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI)
(2 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
10 D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
18 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(8 more)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
12 P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI)
(2 more)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Protein localization by the Cvt pathway GO:0032258
A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Protein localization to phagophore assembly site GO:0034497
Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Early endosome to Golgi transport GO:0034498
The directed movement of substances from early endosomes to the Golgi.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
SNARE complex assembly GO:0035493
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
SNARE complex disassembly GO:0035494
The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Regulation of kinase activity GO:0043549
Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Regulation of kinase activity GO:0043549
Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
12 P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI) P01123 (/IPI)
(2 more)
Golgi vesicle budding GO:0048194
The evagination of the Golgi membrane, resulting in formation of a vesicle.
12 P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI) P01123 (/IGI)
(2 more)
Golgi vesicle docking GO:0048211
The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Reticulophagy GO:0061709
The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
COPII-coated vesicle budding GO:0090114
The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Regulation of endoplasmic reticulum unfolded protein response GO:1900101
Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Pre-mRNA catabolic process GO:1990261
The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).
12 P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP) P01123 (/IMP)
(2 more)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
10 D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) D6XMQ7 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM) Q67BJ9 (/ISM)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
10 D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
6 Q9FPJ4 (/IGI) Q9FPJ4 (/IGI) Q9FPJ4 (/IGI) Q9SEH3 (/IGI) Q9SEH3 (/IGI) Q9SEH3 (/IGI)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
4 Q5AI00 (/IGI) Q5AI00 (/IGI) Q5AI00 (/IGI) Q5AI00 (/IGI)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
4 Q5AI00 (/IMP) Q5AI00 (/IMP) Q5AI00 (/IMP) Q5AI00 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 Q5AI00 (/IMP) Q5AI00 (/IMP) Q5AI00 (/IMP) Q5AI00 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
3 Q9SEH3 (/IMP) Q9SEH3 (/IMP) Q9SEH3 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
2 P28188 (/IDA) P28188 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P28188 (/IEP) P28188 (/IEP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
14 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(4 more)
Phagophore assembly site GO:0000407
Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA) P01123 (/HDA)
(2 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Cis-Golgi network GO:0005801
The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P28188 (/IDA) P28188 (/IDA) Q5AI00 (/IDA) Q5AI00 (/IDA) Q5AI00 (/IDA) Q5AI00 (/IDA) Q9FPJ4 (/IDA) Q9FPJ4 (/IDA) Q9FPJ4 (/IDA) Q9SEH3 (/IDA)
(2 more)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
12 P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA) P01123 (/IDA)
(2 more)
Ciliary pocket GO:0020016
Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes.
10 D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) D6XMQ7 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA) Q67BJ9 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
6 Q9FPJ4 (/IDA) Q9FPJ4 (/IDA) Q9FPJ4 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
5 P28188 (/IDA) P28188 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
4 Q5AI00 (/IDA) Q5AI00 (/IDA) Q5AI00 (/IDA) Q5AI00 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9SEH3 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 Q9SEH3 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q9SEH3 (/IDA) Q9SEH3 (/IDA) Q9SEH3 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
2 P34139 (/HDA) P34140 (/HDA)
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
2 P28188 (/IDA) P28188 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P34139 (/HDA)