The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 343: Ras family gtpase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 P70425 (/IPI) Q5BJQ5 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI) Q92963 (/IPI)
(9 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
12 Q5BJQ5 (/ISS) Q7JMZ0 (/ISS) Q8MT34 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
(2 more)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
12 P70425 (/IDA) Q7JMZ0 (/IDA) Q8MT34 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
(2 more)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
10 Q5BJQ5 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
10 Q7JMZ0 (/TAS) Q8MT34 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
10 P70425 (/IDA) P70426 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
10 Q5BJQ5 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
9 P70425 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
9 Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
9 Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI) Q99578 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P70425 (/IGI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 P70426 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 P70425 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 P70425 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P70426 (/ISO)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
1 P70425 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
11 P70425 (/IGI) Q5BJQ5 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI) Q99578 (/IGI)
(1 more)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
10 P70425 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
10 P70425 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
9 Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS) Q99578 (/NAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
9 P70425 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA) Q92963 (/IDA)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
9 Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
9 Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
9 Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP)
Regulation of Cdc42 protein signal transduction GO:0032489
Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.
9 Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
9 Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP) Q99578 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
9 Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
9 Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
8 Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS) Q92963 (/TAS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
2 Q7JMZ0 (/IMP) Q8MT34 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q7JMZ0 (/IMP) Q8MT34 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q7JMZ0 (/IMP) Q8MT34 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
2 Q7JMZ0 (/IMP) Q8MT34 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 Q5BJQ5 (/IGI)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 P70425 (/ISO)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 Q5BJQ5 (/IMP)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P70425 (/ISO)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 P70425 (/IGI)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 P70426 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 B3DJU3 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P70425 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q5BJQ5 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P70425 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P70425 (/IGI)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 P70425 (/ISO)
Regulation of Cdc42 protein signal transduction GO:0032489
Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.
1 P70425 (/IDA)
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
1 P70425 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P70425 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q5BJQ5 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P70425 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P70425 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
1 B3DJU3 (/IMP)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
1 Q5BJQ5 (/IMP)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
1 P70425 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P70425 (/IDA) P70426 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P70425 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 Q5BJQ5 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 Q5BJQ5 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS) Q99578 (/TAS)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
10 Q5BJQ5 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Dendritic tree GO:0097447
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
10 Q5BJQ5 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS) Q99578 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
9 Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
9 Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA) Q99578 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P70425 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P70425 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70425 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P70425 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 P70425 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P70425 (/ISO)
Dendritic tree GO:0097447
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
1 P70425 (/IDA)