The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 306: ADP-ribosylation factor-like protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
184 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(174 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
177 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(167 more)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
34 P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) Q52NJ5 (/IPI) Q52NJ5 (/IPI)
(24 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
19 P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P40616 (/IDA) P40616 (/IDA)
(9 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
19 P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P40616 (/IPI) P40616 (/IPI)
(9 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
11 P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA)
(1 more)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
11 P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA)
(1 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
176 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(166 more)
Toxin metabolic process GO:0009404
The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Activation of phospholipase D activity GO:0031584
Any process that initiates the activity of inactive phospholipase D.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
19 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P40616 (/IMP) P40616 (/IMP)
(9 more)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
15 Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS) Q8IJ63 (/ISS)
(5 more)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
12 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P61212 (/IMP) P61212 (/IMP)
(2 more)
Toxin metabolic process GO:0009404
The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
11 P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA)
(1 more)
Activation of phospholipase D activity GO:0031584
Any process that initiates the activity of inactive phospholipase D.
11 P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA) P40616 (/IDA)
(1 more)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
11 P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP) P40616 (/IMP)
(1 more)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
8 P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
DsRNA transport GO:0033227
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Secretory granule organization GO:0033363
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
8 P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS) P25160 (/TAS)
Regulation of ER to Golgi vesicle-mediated transport GO:0060628
Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Regulation of protein exit from endoplasmic reticulum GO:0070861
Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Endoplasmic reticulum membrane organization GO:0090158
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.
8 P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP) P25160 (/IMP)
Protein localization to Golgi membrane GO:1903292
A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.
8 P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA)
Protein localization to Golgi membrane GO:1903292
A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.
8 P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI) P25160 (/IPI)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Toxin metabolic process GO:0009404
The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Activation of phospholipase D activity GO:0031584
Any process that initiates the activity of inactive phospholipase D.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Protein localization to Golgi apparatus GO:0034067
A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
4 P61212 (/IMP) P61212 (/IMP) P61212 (/IMP) P61212 (/IMP)
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
176 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(166 more)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
176 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(166 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
169 B2LYL2 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5FY69 (/ISS) B5XET7 (/ISS) B5XET7 (/ISS) C1BKV1 (/ISS)
(159 more)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
23 P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P40616 (/IDA) P40616 (/IDA)
(13 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
19 P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P25160 (/IDA) P40616 (/IDA) P40616 (/IDA)
(9 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS)
(1 more)
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
11 P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS) P40616 (/TAS)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P61211 (/IDA) P61211 (/IDA) P61211 (/IDA) P61211 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
4 P61211 (/ISO) P61211 (/ISO) P61211 (/ISO) P61211 (/ISO)