The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 277: ATP-dependent zinc metalloprotease FtsH

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
8 Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q9UQ90 (/IDA)
ATP-dependent peptidase activity GO:0004176
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.
7 Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
7 Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q3ULF4 (/IPI) Q9UQ90 (/IPI)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 O76867 (/ISS) Q9W4W8 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
2 O76867 (/ISS) Q9W4W8 (/ISS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 Q9UQ90 (/TAS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q381W2 (/ISM)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 Q9UQ90 (/TAS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
7 Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 Q381W2 (/ISM) Q387Q0 (/ISM)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 O76867 (/ISS) Q9W4W8 (/ISS)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
2 Q7TT47 (/IMP) Q9UQ90 (/IMP)
Mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
2 Q7TT47 (/IMP) Q9UQ90 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9UQ90 (/TAS)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q9UQ90 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q3ULF4 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q3ULF4 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q9UQ90 (/TAS)
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
1 Q3ULF4 (/IMP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 Q3ULF4 (/TAS)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 Q3ULF4 (/ISO)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 Q3ULF4 (/ISS)
Mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
1 Q3ULF4 (/ISO)
Mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
1 Q3ULF4 (/ISS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 Q381W2 (/IDA) Q3ULF4 (/IDA) Q57Y25 (/IDA) Q57Y25 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA) Q8I526 (/IDA)
(2 more)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 Q381W2 (/RCA) Q57Y25 (/RCA) Q57Y25 (/RCA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O76867 (/ISS) Q9W4W8 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 Q7TT47 (/ISS) Q9UQ90 (/ISS)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 Q9M895 (/IDA) Q9M895 (/IDA)
Kinetoplast GO:0020023
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
2 Q57Y25 (/IDA) Q57Y25 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q3ULF4 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q4Q5D1 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q387Q0 (/RCA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9UQ90 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q3ULF4 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9UQ90 (/TAS)
M-AAA complex GO:0005745
Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria.
1 Q3ULF4 (/IDA)
Mitochondrial permeability transition pore complex GO:0005757
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
1 Q9UQ90 (/IDA)
Mitochondrial permeability transition pore complex GO:0005757
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
1 Q3ULF4 (/ISO)
Mitochondrial permeability transition pore complex GO:0005757
A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
1 Q3ULF4 (/ISS)