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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 221: Multidrug ABC transporter ATP-binding protein

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ABC-type xenobiotic transporter. [EC: 7.6.2.2]
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1).
  • Formerly EC 3.6.3.44.
 100 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605 A0A024L605
(90 more...)
ABC-type lipid A-core oligosaccharide transporter. [EC: 7.5.2.6]
ATP + H(2)O + lipid A-core oligosaccharide(Side 1) = ADP + phosphate + lipid A-core oligosaccharide(Side 2).
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway.
  • Not to be confused with EC 7.5.2.5, which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
 59 A0A0U4UP76 A0A0U4UP76 A0A0U4UP76 A0A0U5BTY0 A0A0U5BTY0 A0A0U5BTY0 A0A0U5BTY0 A0A0U5BTY0 A0A1S1XR46 A0A1S1XR46
(49 more...)
ABC-type beta-glucan transporter. [EC: 7.5.2.3]
ATP + H(2)O + beta-glucan(Side 1) = ADP + phosphate + beta-glucan(Side 2).
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • An enzyme found in Gram-negative bacteria that exports beta-glucans.
  • Formerly EC 3.6.3.42.
 53 A0A0F6AQP2 A0A0F6AQP2 A0A0F6AQP2 A0A0F6AQP2 A0A0F6AQP2 A0A0F6AQP2 A0A0M1WDQ9 A0A0M1WDQ9 A0A0M1WDQ9 A0A0M1WDQ9
(43 more...)