View in Gene3D

CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1079: carbohydrate sulfotransferase 15

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase. [EC: 2.8.2.33]
(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N- acetylgalactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O- sulfo-N-acetyl-D-galactosamine. (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N- acetylgalactosamine = adenosine 3',5'-bisphosphate + [chondroitin]-4,6- di-O-sulfo-N-acetyl-D-galactosamine.
  • The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate.
  • Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not.
  • Differs from EC 2.8.2.17 in being able to use both chondroitin and dermatan as effective substrates.
 3 Q7LFX5 Q8CHI9 Q91XQ5