The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 132: Two-component response regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
6 O49397 (/ISS) O49397 (/ISS) O49397 (/ISS) P62598 (/ISS) Q9FXD6 (/ISS) Q9FXD6 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
6 O49397 (/ISS) O49397 (/ISS) O49397 (/ISS) P62598 (/ISS) Q9FXD6 (/ISS) Q9FXD6 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 O49397 (/IDA) O49397 (/IDA) O49397 (/IDA) Q9FXD6 (/IDA) Q9FXD6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q948L2 (/IPI) Q94LW1 (/IPI) Q9AV93 (/IPI) Q9FXD6 (/IPI) Q9FXD6 (/IPI)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
2 Q94LW1 (/IDA) Q9AV93 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q5SML5 (/IDA) Q5SML5 (/IDA)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
6 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI) Q9FXD6 (/IGI) Q9FXD6 (/IGI)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
6 O49397 (/TAS) O49397 (/TAS) O49397 (/TAS) P62598 (/TAS) Q9FXD6 (/TAS) Q9FXD6 (/TAS)
Regulation of root meristem growth GO:0010082
Any process involved in maintaining the size and shape of a root meristem.
6 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP) Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
4 Q5SML5 (/IDA) Q5SML5 (/IDA) Q94LW1 (/IDA) Q9AV93 (/IDA)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
4 O49397 (/IEP) O49397 (/IEP) O49397 (/IEP) P62598 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Regulation of chlorophyll biosynthetic process GO:0010380
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Maintenance of shoot apical meristem identity GO:0010492
The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Regulation of anthocyanin metabolic process GO:0031537
Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
4 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP)
Shoot system development GO:0048367
The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Cellular response to cytokinin stimulus GO:0071368
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
4 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP)
Primary root development GO:0080022
The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle.
4 O49397 (/IGI) O49397 (/IGI) O49397 (/IGI) P62598 (/IGI)
Regulation of cytokinin-activated signaling pathway GO:0080036
Any process that modulates the frequency, rate or extent of cytokinin signaling.
4 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP)
Regulation of seed growth GO:0080113
Any process that modulates the frequency, rate or extent of growth of the seed of an plant.
4 O49397 (/IMP) O49397 (/IMP) O49397 (/IMP) P62598 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
3 Q948L2 (/IEP) Q94LW1 (/IEP) Q9AV93 (/IEP)
Cytokinin-activated signaling pathway GO:0009736
A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q5SML5 (/IDA) Q5SML5 (/IDA)
Regulation of abscisic acid-activated signaling pathway GO:0009787
Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5SML5 (/IDA) Q5SML5 (/IDA)
Regulation of jasmonic acid mediated signaling pathway GO:2000022
Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)
Regulation of salicylic acid mediated signaling pathway GO:2000031
Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway.
2 Q9FXD6 (/IMP) Q9FXD6 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 O49397 (/IDA) O49397 (/IDA) O49397 (/IDA) P62598 (/IDA) Q5SML5 (/IDA) Q5SML5 (/IDA) Q6K8X6 (/IDA) Q9AV93 (/IDA)