The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase S8/S53 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Proprotein convertase type 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
3 P16519 (/IDA) P21661 (/IDA) P21661 (/IDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 P21661 (/IDA) P21661 (/IDA)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 G5ECN9 (/IMP) P28841 (/IMP)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 P21661 (/ISO) P21661 (/ISO)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 P21661 (/TAS) P21661 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P16519 (/IPI) P28841 (/IPI)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 Q9UAE7 (/IDA) Q9VBC7 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P21661 (/ISO) P21661 (/ISO)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P28841 (/EXP)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P28841 (/IPI)
FBXO family protein binding GO:0098770
Interacting selectively and non-covalently with any member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.
1 G5ECN9 (/IPI)

There are 56 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
6 P28841 (/ISS) Q03333 (/ISS) Q5REC2 (/ISS) Q5REC2 (/ISS) Q5REC2 (/ISS) Q9GLR0 (/ISS)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
5 P21661 (/IMP) P21661 (/IMP) P28841 (/IMP) Q9UAE7 (/IMP) Q9VBC7 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 P16519 (/IDA) Q9UAE7 (/IDA) Q9VBC7 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 P21661 (/IMP) P21661 (/IMP) P28841 (/IMP)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
3 P16519 (/IDA) P21661 (/IDA) P21661 (/IDA)
Instar larval or pupal development GO:0002165
The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
2 Q9UAE7 (/IMP) Q9VBC7 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 P21661 (/ISO) P21661 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
2 P21661 (/IEP) P21661 (/IEP)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
2 P21661 (/IDA) P21661 (/IDA)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
2 P21661 (/ISO) P21661 (/ISO)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
2 P21661 (/IDA) P21661 (/IDA)
Insulin processing GO:0030070
The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.
2 P21661 (/ISO) P21661 (/ISO)
Carbohydrate homeostasis GO:0033500
A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
2 Q9UAE7 (/IMP) Q9VBC7 (/IMP)
Enkephalin processing GO:0034230
The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide.
2 P21661 (/IDA) P21661 (/IDA)
Islet amyloid polypeptide processing GO:0034231
The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).
2 P21661 (/ISO) P21661 (/ISO)
Larval wandering behavior GO:0035180
The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction.
2 Q9UAE7 (/IMP) Q9VBC7 (/IMP)
Hatching behavior GO:0035187
The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.
2 Q9UAE7 (/IMP) Q9VBC7 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9GLR0 (/ISS)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 G5ECN9 (/IGI)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 G5ECN9 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
1 G5ECN9 (/IGI)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q9GLR0 (/ISS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 G5ECN9 (/IGI)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
1 G5ECN9 (/IGI)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 G5ECN9 (/IGI)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 G5ECN9 (/IMP)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 G5ECN9 (/IGI)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 G5ECN9 (/IMP)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
1 Q9GLR0 (/ISS)
Insulin processing GO:0030070
The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.
1 P16519 (/IDA)
Insulin processing GO:0030070
The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.
1 G5ECN9 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 G5ECN9 (/IMP)
Enkephalin processing GO:0034230
The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide.
1 P16519 (/ISS)
Islet amyloid polypeptide processing GO:0034231
The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).
1 P28841 (/IMP)
Islet amyloid polypeptide processing GO:0034231
The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).
1 P16519 (/ISS)
Regulation of backward locomotion GO:0043058
Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.
1 G5ECN9 (/IGI)
R8 cell fate specification GO:0045464
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
1 Q9VBC7 (/IMP)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 G5ECN9 (/IGI)
Positive regulation of digestive system process GO:0060456
Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
1 G5ECN9 (/IMP)
Negative regulation of turning behavior involved in mating GO:0061096
Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.
1 G5ECN9 (/IMP)
Neuropeptide processing GO:0061837
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide.
1 G5ECN9 (/IMP)
Regulation of locomotion involved in locomotory behavior GO:0090325
Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
1 G5ECN9 (/IGI)
Regulation of locomotion involved in locomotory behavior GO:0090325
Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
1 G5ECN9 (/IMP)
Positive regulation of locomotion involved in locomotory behavior GO:0090326
Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
1 G5ECN9 (/IMP)
Dibasic protein processing GO:0090472
Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein.
1 G5ECN9 (/IMP)
Arg-arg specific dibasic protein processing GO:0090474
Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein.
1 G5ECN9 (/IMP)
Regulation of neuromuscular synaptic transmission GO:1900073
Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission.
1 G5ECN9 (/IGI)
Positive regulation of oviposition GO:1901046
Any process that activates or increases the frequency, rate or extent of oviposition.
1 G5ECN9 (/IMP)
Regulation of eating behavior GO:1903998
Any process that modulates the frequency, rate or extent of eating behavior.
1 G5ECN9 (/IMP)
Response to serotonin GO:1904014
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.
1 G5ECN9 (/IMP)
Negative regulation of dense core granule transport GO:1904810
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport.
1 G5ECN9 (/IMP)
Positive regulation of forward locomotion GO:1905850
Any process that activates or increases the frequency, rate or extent of forward locomotion.
1 G5ECN9 (/IGI)
Positive regulation of forward locomotion GO:1905850
Any process that activates or increases the frequency, rate or extent of forward locomotion.
1 G5ECN9 (/IMP)
Positive regulation of backward locomotion GO:1905852
Any process that activates or increases the frequency, rate or extent of backward locomotion.
1 G5ECN9 (/IGI)
Negative regulation of dauer entry GO:1905910
Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry.
1 G5ECN9 (/IGI)
Positive regulation of lipid localization GO:1905954
Any process that activates or increases the frequency, rate or extent of lipid localization.
1 G5ECN9 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P28841 (/ISS) Q03333 (/ISS) Q5REC2 (/ISS) Q5REC2 (/ISS) Q5REC2 (/ISS) Q9GLR0 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P16519 (/IDA) P21661 (/IDA) P21661 (/IDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
3 P21661 (/TAS) P21661 (/TAS) P28841 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q9UAE7 (/IDA) Q9VBC7 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P21661 (/ISO) P21661 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P21661 (/ISO) P21661 (/ISO)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 P21661 (/TAS) P21661 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P21661 (/ISO) P21661 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P21661 (/ISO) P21661 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P21661 (/ISO) P21661 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 P21661 (/ISO) P21661 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 P21661 (/ISO) P21661 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P16519 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P16519 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 G5ECN9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P28841 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P28841 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P28841 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P16519 (/IDA)