The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Carbamoyl-phosphate synthase large chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004088
Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
14 P20054 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA)
(4 more)
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004088
Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
8 Q83C50 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
3 P00968 (/IMP) P00968 (/IMP) P00968 (/IMP)
Carbamoyl-phosphate synthase (ammonia) activity GO:0004087
Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P00968 (/IPI) P00968 (/IPI) P00968 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 P00968 (/IMP) P00968 (/IMP) P00968 (/IMP)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
Aspartate carbamoyltransferase activity GO:0004070
Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
2 Q5B0D1 (/RCA) Q5B0D1 (/RCA)
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004088
Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
2 Q5B0D1 (/RCA) Q5B0D1 (/RCA)
Aspartate carbamoyltransferase activity GO:0004070
Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
1 P20054 (/IDA)
Dihydroorotase activity GO:0004151
Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).
1 P20054 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 O94313 (/ISM)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
12 P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA)
(2 more)
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
12 P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA) P38100 (/IDA)
(2 more)
Arginine biosynthetic process GO:0006526
The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
8 P03965 (/IMP) P03965 (/IMP) P03965 (/IMP) P03965 (/IMP) P03965 (/IMP) P03965 (/IMP) P03965 (/IMP) P03965 (/IMP)
Pyrimidine ribonucleotide biosynthetic process GO:0009220
The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
8 Q83C50 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS) Q9KPH9 (/ISS)
Pyrimidine nucleobase biosynthetic process GO:0019856
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
4 P00968 (/IMP) P00968 (/IMP) P00968 (/IMP) Q18990 (/IMP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
3 P00968 (/IMP) P00968 (/IMP) P00968 (/IMP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
2 Q5B0D1 (/RCA) Q5B0D1 (/RCA)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
2 Q5B0D1 (/RCA) Q5B0D1 (/RCA)
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
2 Q5B0D1 (/IEP) Q5B0D1 (/IEP)
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
1 O94313 (/IC)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q18990 (/IMP)
'de novo' pyrimidine nucleobase biosynthetic process GO:0006207
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
1 P20054 (/ISS)
Arginine biosynthetic process GO:0006526
The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 O94313 (/EXP)
Arginine biosynthetic process GO:0006526
The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 Q42601 (/NAS)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
1 P20054 (/IDA)
Cellular response to phosphate starvation GO:0016036
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
1 Q42601 (/IEP)
Pharynx development GO:0060465
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
1 Q18990 (/IMP)
Pharyngeal gland morphogenesis GO:1905905
The developmental process by which a pharyngeal gland is generated and organized.
1 Q18990 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbamoyl-phosphate synthase complex GO:0005951
A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
12 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA) P03965 (/IDA) P03965 (/IDA) P03965 (/IDA) P03965 (/IDA) P03965 (/IDA) P03965 (/IDA) P03965 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P9WPK3 (/HDA) P9WPK3 (/HDA) P9WPK3 (/HDA) P9WPK3 (/HDA) P9WPK3 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P00968 (/IDA) P00968 (/IDA) P00968 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O94313 (/HDA)
Carbamoyl-phosphate synthase complex GO:0005951
A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
1 O94313 (/ISO)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q42601 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q42601 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q42601 (/IDA)