The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: NDRG family member 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 Q8BTG7 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI) Q9ULP0 (/IPI)
(1 more)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
10 Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
10 Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
10 Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS)
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
10 Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
10 Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
3 A0A0R4ICQ1 (/IMP) A6XCT1 (/IMP) Q1JPS5 (/IMP)
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
3 A0A0R4ICQ1 (/IMP) A6XCT1 (/IMP) Q1JPS5 (/IMP)
Clustering of voltage-gated sodium channels GO:0045162
The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.
3 A0A0R4ICQ1 (/IMP) A6XCT1 (/IMP) Q1JPS5 (/IMP)
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
3 A0A0R4ICQ1 (/IMP) A6XCT1 (/IMP) Q1JPS5 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q9Z2L9 (/IEP)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 Q8BTG7 (/IMP)
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
1 Q8BTG7 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9Z2L9 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8BTG7 (/ISO)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
1 Q8BTG7 (/ISO)
Vesicle docking GO:0048278
The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
1 Q8BTG7 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 Q8BTG7 (/ISO)
Cell migration involved in heart development GO:0060973
The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.
1 Q8BTG7 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q8BTG7 (/ISO)
Regulation of endocytic recycling GO:2001135
Any process that modulates the frequency, rate or extent of endocytic recycling.
1 Q8BTG7 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 Q8BTG7 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS) Q9ULP0 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
10 Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS) Q9ULP0 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
10 Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA) Q9ULP0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BTG7 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z2L9 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BTG7 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9Z2L9 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q8BTG7 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q8BTG7 (/ISO)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 Q8BTG7 (/IDA)