The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: Monoglyceride lipase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
4 O35678 (/IDA) Q8R431 (/IDA) Q99685 (/IDA) Q99685 (/IDA)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
3 Q8R431 (/TAS) Q99685 (/TAS) Q99685 (/TAS)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
2 Q99685 (/TAS) Q99685 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q99685 (/IPI) Q99685 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q99685 (/IPI) Q99685 (/IPI)
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
1 Q8R431 (/IDA)
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
1 O35678 (/ISO)
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
1 Q8R431 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O35678 (/ISO)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 O35678 (/IMP)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 O35678 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of signal transduction GO:0009966
Any process that modulates the frequency, rate or extent of signal transduction.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
3 O35678 (/IDA) Q99685 (/IDA) Q99685 (/IDA)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
2 Q99685 (/TAS) Q99685 (/TAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q99685 (/TAS) Q99685 (/TAS)
Acylglycerol acyl-chain remodeling GO:0036155
Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains.
2 Q99685 (/TAS) Q99685 (/TAS)
Monoacylglycerol catabolic process GO:0052651
The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
2 O35678 (/IDA) Q8R431 (/IDA)
Monoacylglycerol catabolic process GO:0052651
The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
2 Q99685 (/ISS) Q99685 (/ISS)
Regulation of endocannabinoid signaling pathway GO:2000124
Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway.
2 Q99685 (/ISS) Q99685 (/ISS)
Regulation of signal transduction GO:0009966
Any process that modulates the frequency, rate or extent of signal transduction.
1 O35678 (/IMP)
Arachidonic acid metabolic process GO:0019369
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
1 O35678 (/IMP)
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
1 O35678 (/IMP)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
1 O35678 (/IMP)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
1 O35678 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 O35678 (/IMP)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
1 O35678 (/IMP)
Monoacylglycerol catabolic process GO:0052651
The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
1 O35678 (/ISO)
Long-term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
1 O35678 (/IMP)
Negative regulation of blood vessel diameter GO:0097756
Any process that decreases the diameter of blood vessels.
1 Q8R431 (/IMP)
Negative regulation of blood vessel diameter GO:0097756
Any process that decreases the diameter of blood vessels.
1 O35678 (/ISO)
Regulation of endocannabinoid signaling pathway GO:2000124
Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway.
1 O35678 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 A0A0C4DFN3 (/IDA) A0A0C4DFN3 (/IDA) A0A0C4DFN3 (/IDA) Q99685 (/IDA) Q99685 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
3 Q8R431 (/ISS) Q99685 (/ISS) Q99685 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q99685 (/TAS) Q99685 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q99685 (/TAS) Q99685 (/TAS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 O35678 (/IDA) Q8R431 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O35678 (/ISO)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 Q8R431 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O35678 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 O35678 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O35678 (/IDA)
Varicosity GO:0043196
Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
1 O35678 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O35678 (/ISO)