The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Histone-lysine N-methyltransferase, H3 lysine-79 s...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
4 H9LAN6 (/IDA) Q679P5 (/IDA) Q6XZL8 (/IDA) Q8TEK3 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8TEK3 (/IPI)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q8TEK3 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q8TEK3 (/TAS)
Histone methyltransferase activity (H3-K79 specific) GO:0031151
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein.
1 Q8INR6 (/IMP)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
3 A0A2R8QAW0 (/IMP) A8E7B7 (/IMP) F1Q4W7 (/IMP)
Histone H3-K79 methylation GO:0034729
The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
3 A0A2R8QAW0 (/IMP) A8E7B7 (/IMP) F1Q4W7 (/IMP)
Intestinal epithelial structure maintenance GO:0060729
A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
3 A0A2R8QAW0 (/IMP) A8E7B7 (/IMP) F1Q4W7 (/IMP)
Regulation of transcription regulatory region DNA binding GO:2000677
Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 Q8INR6 (/IGI)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 Q8INR6 (/IMP)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
1 Q8INR6 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8TEK3 (/IDA)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q8INR6 (/IMP)
Telomere organization GO:0032200
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.
1 Q8TEK3 (/TAS)
Histone H3-K79 methylation GO:0034729
The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone.
1 Q8TEK3 (/IDA)
Histone H3-K79 methylation GO:0034729
The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone.
1 Q8INR6 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8TEK3 (/IDA)
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
1 Q8TEK3 (/IDA)
Chromatin-mediated maintenance of transcription GO:0048096
Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.
1 Q8INR6 (/IGI)
Chromatin-mediated maintenance of transcription GO:0048096
Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.
1 Q8INR6 (/IMP)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 Q8INR6 (/IMP)
Regulation of transcription regulatory region DNA binding GO:2000677
Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
1 Q8TEK3 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 H9LAN6 (/ISO) Q679P5 (/ISO) Q6XZL8 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8TEK3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8INR6 (/IMP)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8TEK3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8TEK3 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8TEK3 (/IDA)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
1 Q8INR6 (/IC)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8TEK3 (/IDA)