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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Ribosomal RNA large subunit methyltransferase K/L

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (guanine(2445)-N(2))-methyltransferase. [EC: 2.1.1.173]
S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(2445) in 23S rRNA.
  • The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.
  • The enzyme specifically methylates guanine(2445) at N(2) in 23S rRNA.
  • Formerly EC 2.1.1.52.
 3732 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5
(3722 more...)
23S rRNA (guanine(2069)-N(7))-methyltransferase. [EC: 2.1.1.264]
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(2069) in 23S rRNA.
  • The enzyme specifically methylates guanine(2069) at position N7 in 23S rRNA.
  • In gamma-proteobacteria the enzyme also catalyzes EC 2.1.1.173, while in beta-proteobacteria the activities are carried out by separate proteins.
  • The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well.
 3728 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5 A0A026UHK5
(3718 more...)