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CATH Superfamily 3.40.50.1220

TPP-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: Thi3p

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Branched-chain-2-oxoacid decarboxylase. [EC: 4.1.1.72]
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO(2).
  • Acts on a number of 2-oxo acids, with a high affinity toward branched-chain substrates.
  • The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for biosynthesis of branched-chain fatty acids.
 4 N1P457 N1P457 Q07471 Q07471