Repression of transcription of ribosomal DNA by altering the structure of chromatin.

The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.

The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.

Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.

The formation or destruction of chromatin structures.

Repression of transcription of telomeric DNA by altering the structure of chromatin.

The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.

Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.

The process in which a telomere is maintained in a specific location at the nuclear periphery.

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.

Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification.

A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.

A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.

Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.