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CATH Superfamily 3.40.50.1220

TPP-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: NAD-dependent histone deacetylase SIR2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NAD-dependent histone deacetylase activity GO:0017136
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
 5 P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA)
NAD-independent histone deacetylase activity GO:0045129
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone.
 5 P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
 3 Q6FNA6 (/IDA) Q6FNA6 (/IDA) Q6FWI7 (/IDA)
NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
 1 C8V3W5 (/IMP)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
 5 P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
 5 P53685 (/IGI) P53685 (/IGI) P53685 (/IGI) P53685 (/IGI) P53685 (/IGI)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
 5 P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP)
Negative regulation of mitotic recombination GO:0045950
Any process that inhibits or decreases the rate of DNA recombination during mitosis.
 5 P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP)
Regulation of thiamine biosynthetic process GO:0070623
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.
 5 P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP) P53685 (/IMP)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
 2 Q6FNA6 (/IMP) Q6FNA6 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Set3 complex GO:0034967
A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
 5 P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA) P53685 (/IDA)