The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

RNA polymerase II accessory factor, Cdc73 C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RNA polymerase II accessory factor, Cdc73 C-terminal domain

This superfamily entry represents the C-terminal Cdc73 (Cell division control protein 73) domain that plays role in transcription elongation. The C-terminal domain contains a large but comparatively flat surface of highly conserved residues, devoid of ligand. Deletion of the Cdc73 C-domain significantly reduces Paf1C occupancy on active genes, which means that the Cdc73 C-domain plays a role in promoting association of Paf1C with chromatin.

Cdc73 is an RNA polymerase II accessory factor PMID:8812838, and forms part of the Paf1 complex that has roles in post-initiation events PMID:9032243. The C-terminus adopts a Ras-like fold that is highly similar to GTPases of the Ras superfamily. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase PMID:9891041.

INTERPRO:IPR031336, PFAM:PF05179,DOI:10.1074/jbc.M111.325647

GO Diversity

Unique GO annotations
60 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1448 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 13
Unique EC:
Unique GO: 60
Unique Species: 1448