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CATH Superfamily 3.40.50.11860

Diphthamide synthesis DPH1/DPH2 domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Diphthamide synthesis DPH1/DPH2 domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: 2-(3-amino-3-carboxypropyl)histidine synthase subu...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-(3-amino-3-carboxypropyl)histidine synthase. [EC: 2.5.1.108]
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine.
  • Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical.
  • The enzyme is present in archae and eukaryotes but not in eubacteria.
  • Part of diphthamide biosynthesis.
  • Formerly EC 2.5.1.n7.
 4 P0CN18 P0CN18 P0CN19 P0CN19